We have isolated several H-2K(b)-alloreactive cytotoxic T cell clones and analyzed their reactivity for several forms of H-2K(b). These cytotoxic T lymphocytes (CTL) were elicited by priming with a skin graft followed by in vitro stimulation using stimulator cells that express an H-2K(b) molecule unable to bind CD8. In contrast to most alloreactive T cells, these CTL were able to recognize H-2K...

A permutation σ ∈ Sn is a k-separator if all of its patterns of length k are distinct. Let F (k) denote the maximal length of a k-separator. Hegarty (2013) showed that k + ⌊√ 2k − 1 ⌋ − 1 6 F (k) 6 k + ⌊√ 2k − 3 ⌋ , and conjectured that F (k) = k + ⌊√ 2k − 1 ⌋ − 1. This paper will strengthen the upper bound to prove the conjecture for all sufficiently large k (in particular, for all k > 320801).

Abstract. Given arbitrary integers k and d with 0 ≤ 2k ≤ d, we construct a Gorenstein Fano polytope P ⊂ R of dimension d such that (i) its Ehrhart polynomial i(P , n) possesses d distinct roots; (ii) i(P , n) possesses exactly 2k imaginary roots; (iii) i(P , n) possesses exactly d − 2k real roots; (iv) the real part of each of the imaginary roots is equal to −1/2; (v) all of the real roots belo...

We consider extremal problems for subgraphs of pseudorandom graphs. Our results implies that for (n, d, λ)-graphs Γ satisfying λ2k−1 ≪ d 2k n (log n)−2(k−1)(2k−1) any subgraph G ⊂ Γ not containing a cycle of length 2k + 1 has relative density at most 12 + o(1). Up to the polylog-factor the condition on λ is best possible and was conjectured by Krivelevich, Lee and Sudakov.

In the Hamiltonian formulation of chiral 2k-form electrodynamics, potential on (4k+1)-space is defined up to addition either (i) a closed $2k$-form or (ii) an exact 2k-form, depending choice chirality constraint. Case realized by Floreanini-Jackiw 2D boson (for k=0) and its Henneaux-Teitelboim generalisation k>0. For all k, but focusing 6D case, we present simple Lorentz-invariant model that re...

Eukaryotic elongation factor 2 kinase (eEF-2K), through its phosphorylation of elongation factor 2 (eEF2), provides a mechanism by which cells can control the rate of the elongation phase of protein synthesis. The activity of eEF-2K is increased in rapidly proliferating malignant cells, is inhibited during mitosis, and may contribute to the promotion of autophagy in response to anti-cancer ther...

Interference or competition between CD8(+) T cells restricted by distinct MHC-I molecules can be a powerful means to establish an immunodominant response. However, its importance during infections is still questionable. In this study, we describe that following infection of mice with the human pathogen Trypanosoma cruzi, an immunodominant CD8(+) T cell immune response is developed directed to a...

A wealth of data has accumulated on the structure of mouse MHC class I (MHCI) molecules encoded by the H-2(b) and H-2(d) haplotypes. In contrast, there is a dearth of structural data regarding H-2(k)-encoded molecules. Therefore, the structures of H-2K(k) complexed to an octameric peptide from influenza A virus (HA(259-266)) and to a nonameric peptide from SV40 (SV40(560-568)) have been determi...