MLD is characterized by accumulation of sulfatides in the brain. Vitamin K regulates two enzymes in sphingolipid biosynthesis and warfarin is known to lower brain sulfatides in rats and mice. We hypothesized that warfarin may mitigate the MLD phenotype by reducing the formation of sulfatides. This compassionate study recruited four advanced patients with clinical, biochemical and genetic confir...

あらまし マルチ送受信アンテナ(MIMO)空間多重を用いる直交周波数分割多重(OFDM)伝送の信号分離法とし て,QR 分解と M アルゴリズムを用いる演算量削減型最尤検出(QRM-MLD)が MLD に近い誤り率特性を達成するこ とが知られている.筆者らは以前,シングルキャリア(SC)伝送を対象に最小平均二乗誤差規範に基づく周波数領域 等化(MMSE-FDE)出力より事後確率を計算してシンボル候補を絞り込むことで演算量を削減する,2 ステップ QRM-MLブロック信号検出(QRM-MLBD)を提案した.2ステップQRM-MLD は SC伝送だけではなく,MIMO-OFDM 伝送にも適用できる.本稿では,MMSE 規範に基づく線形検出(MMSED)を第 1 ステップに用いる 2 ステップ QRM-MLD を MIMO-OFDM 伝送に適用する.QRM-MLD においては送信信号の検出...

We report a novel route for enhancing the humidity resistance of SnO2 nanowires (NWs; widely used metal oxide semiconductor gas sensors) based on their coating with humidity-resistant nanomembrane. A conformal thin film was deposited by Molecular Layer Deposition (MLD) NWs using trimethylaluminum and ethylene glycol as precursors (100 MLD cycles), followed oxidation in air at 400 °C. In conditi...

OBJECTIVE Metachromatic leukodystrophy (MLD) is an inherited lysosomal disorder due to a deficiency in arylsulfatase A with progressive demyelination and neurological decline. This retrospective MRI study investigated the extent of cortical involvement at time of diagnosis, and clinical correlates to both conventional and regional volumetric measures of brain involvement. METHODS 3D-T1-weight...

Despite the benefits of successful percutaneous coronary interventions (PCIs) for chronic total occlusion (CTO) lesions, PCIs of CTO lesions still carry a high rate of adverse events, including in-stent restenosis (ISR). Because previous reports have not specifically investigated the intravascular ultrasound (IVUS) predictors of ISR in CTO lesions, we focused on these predictors. We included 12...

The mld mutation is a complex genetic lesion affecting the myelin basic protein (MBP) locus in the mouse. The mutation consists of a variety of DNA rearrangements including: tandem duplication of the MBP structural gene, partial inversion of the 3' end of the upstream gene copy, duplication of a region flanking the rearrangement junction in the upstream copy and insertion between the two gene c...

The purpose of the systematic review mathematics intervention syntheses was to identify patterns and gaps in content areas, instructional strategies, effect sizes, definitions learning disabilities (LD), LD (MLD), difficulty (MD). Using rigorous inclusion criteria, we evaluated 36 that included 836 studies with 32,495 participants. Although each synthesis stated a focus on LD, MLD, or MD, few s...