Combined pulmonary fibrosis and emphysema (CPFE) is an important risk factor for lung cancer (LC), because most patients with CPFE are smokers. However, the histological characteristics of LC in patients with CPFE (LC-CPFE) remain unclear. We conducted this study to explore the clinicopathological characteristics of LC-CPFE. We retrospectively reviewed data from 985 patients who underwent resec...

Motivation and attention can have a profound influence on perception, learning and memory. Neuromodulatory systems, especially the noradrenergic (NE) system, co-vary with psychological states to modulate cortical arousal, influence sensory processing and promote synaptic plasticity. There is even some suggestion that the NE system might facilitate functional recovery after brain damage. Post-sy...

Motivation and attention can have a profound influence on perception, learning and memory. Neuromodulatory systems, especially the noradrenergic (NE) system, co-vary with psychological states to modulate cortical arousal, influence sensory processing and promote synaptic plasticity. There is even some suggestion that the NE system might facilitate functional recovery after brain damage. Post-sy...

There have been numerous studies of liquid crystal (LC) convection using sandwich-type LC cells under AC voltage. In contrast to previous LC convection studies under AC voltage, we propose the use of a binary self-assembled monolayer (SAM) with a redox-active Ru complex and insulating octadecyl phosphonic acid (C18) molecules on an indium tin oxide (ITO) surface as the electrode of sandwich-typ...

Leukocyte protein tyrosine phosphatase (LC-PTP)/hemopoietic PTP is a human cytoplasmic PTP that is predominantly expressed in the hemopoietic cells. Recently, it was reported that hemopoietic PTP inhibited TCR-mediated signal transduction. However, the precise mechanism of the inhibition was not identified. Here we report that extracellular signal-regulated kinase (ERK) is the direct target of ...

BACKGROUND & AIMS Thrombocytopenia is common in liver cirrhosis (LC) but the mechanisms are not fully understood. The purpose of our work was to evaluate platelet kinetics in LC with different etiologies by examining platelet production and destruction. METHODS Ninety-one consecutive LC patients (36 HCV, 49 alcoholics, 15 HBV) were enrolled. As controls, 25 subjects with idiopathic thrombocyt...

PURPOSE Lamina cribrosa (LC) morphology could be implicated in the progression of glaucoma. To date, no established, quantifiable parameter to assess LC shape in vivo exists. We aim to introduce a new global shape index for the anterior LC (LC-GSI) and to identify associations with ocular factors in a healthy Indian population. METHODS Optical coherence tomography (OCT) scans of the optic ner...

This study presents evidence that alpha 2-receptors in the locus coeruleus (LC) regulate the responsiveness of LC neurons to excitatory stimuli. In the first experiment, intravenous administration of the alpha 2-adrenergic antagonist idazoxan markedly potentiated the responses of LC neurons to the excitatory stimulus of contralateral hind paw compression (PC). Increased responsiveness of LC neu...