نتایج جستجو برای: شاخص ed50

تعداد نتایج: 76082  

2013
Laura Milan-Lobo Johan Enquist Richard M. van Rijn Jennifer L. Whistler

Delta (DOR) and mu opioid receptors (MOR) can complex as heteromers, conferring functional properties in agonist binding, signaling and trafficking that can differ markedly from their homomeric counterparts. Because of these differences, DOR/MOR heteromers may be a novel therapeutic target in the treatment of pain. However, there are currently no ligands selective for DOR/MOR heteromers, and, c...

Journal: :International journal of clinical and experimental medicine 2015
Dongyue Zheng Guowei Wu Peishun Qin Bin Ji Lisha Ye Tong Shi Huang Huang Lexiao Jin

Adjuvant sufentanil could achieve effective spinal anesthesia with low dose of hyperbaric ropivacaine for cesarean delivery. Two previous studies had calculated the 50% effective dose (ED50) of intrathecal ropivacaine coadministered with sufentanil for cesarean delivery. However, the 95% effective dose (ED95) of intrathecal hyperbaric ropivacaine coadministered with sufentanil for cesarean deli...

Journal: :Journal of virology 1997
R K Williams S E Straus

Herpes simplex virus type 2 (HSV-2) interacts with cell surface glycosaminoglycans during virus attachment. Glycoprotein B of HSV-2 can potentially mediate the interaction between the virion and cell surface glycosaminoglycans. To determine the specificity, kinetics, and affinity of these interactions, we used plasmon resonance-based biosensor technology to measure HSV-2 glycoprotein binding to...

Journal: :Molecules 2015
Fabrizio Araniti Raffaella Mancuso Antonio Lupini Salvatore V Giofrè Francesco Sunseri Bartolo Gabriele Maria Rosa Abenavoli

Coumarin is a natural compound well known for its phytotoxic potential. In the search for new herbicidal compounds to manage weeds, three synthetic derivatives bearing the coumarin scaffold (1-3), synthesized by a carbonylative organometallic approach, were in vitro assayed on germination and root growth of two noxious weeds, Amaranthus retroflexus and Echinochloa crus-galli. Moreover, the synt...

Journal: :British journal of anaesthesia 1993
M Naguib M Abdulatif A al-Ghamdi I Hamo R Nouheid

We have studied the dose-response relationships for neostigmine and edrophonium during antagonism of neuromuscular block induced by mivacurium chloride. Sixty-four ASA group I or II adults were given mivacurium 0.15 mg kg-1 during fentanyl-thiopentone-nitrous oxide-isoflurane anaesthesia. Train-of-four stimulation (TOF) was applied to the ulnar nerve every 10 s, and the force of contraction of ...

Journal: :Biochemical and biophysical research communications 1990
A Aström U Pettersson A Krust P Chambon J J Voorhees

We have developed an assay where the potency of retinoids in retinoic acid receptor (RAR) mediated transcriptional activation can be rapidly evaluated. In this assay hRAR-alpha, hRAR-beta and hRAR-gamma were expressed in CV-1 cells together with a reporter gene containing a retinoic acid responsive element (TRE3-tk-CAT). Concentrations required to obtain half-maximum induction (ED50) of CAT-act...

Journal: :Endocrinology 1997
Diane Nehar Claire Mauduit Fayc Al Boussouar Mohamed Benahmed

By using, as a model, cultured testicular immature Sertoli cells, the action of tumor necrosis factor-alpha (TNF alpha) and the site of action of the cytokine on lactate production were studied. TNF alpha stimulated in a time- and dose-dependent manner (with an ED50 of 0.1 nM) Sertoli cell lactate production. Two major sites involved in TNF alpha action were identified. Firstly, TNF alpha was s...

Journal: :Journal of biomedical optics 2014
Brian J Lund David J Lund Peter R Edsall Victor D Gaines

The laser-induced retinal injury thresholds for repetitive-pulse exposures to 100-μs-duration pulses at a wavelength of 532 nm have been determined for exposures of up to 1000 pulses in an in vivo model. The ED50 was measured for pulse repetition frequencies of 50 and 1000 Hz. Exposures to collimated beams producing a minimal retinal beam spot and to divergent beams producing a 100-μm-diameter ...

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2002
K K Borowicz M Swiader W Zgrajka C Sawulski W A Turski S J Czuczwar

Aminophylline (50-100 mg/kg) and strychnine (0.125-0.5 mg/kg) significantly raised the ED50 values of LY 300164 against maximal electroshock in mice, from 4 to 8 mg/kg (aminophylline 100 mg/kg) and from 3.6 to 11.5 mg/kg (strychnine 0.5 mg/kg). Also, aminophylline (25-50 mg/kg) and strychnine (0.125-0.25 mg/kg) increased the ED50 value of lamotrigine in this test, for instance from 5.5 to 8.0 m...

Journal: :حفاظت گیاهان 0
مسعود آزاد ابراهیم ایزدی دربندی محمدحسن راشد محصل مهدی نصیری محلاتی

in order to study the effect of soil nitrogen content and water hardness on glyphosate efficacy on common lambsquarter (chenopodium album l.) and redroot pigweed (amaranthus retroflexus l.) control, an experiment was carried out as a completely randomized design in a factorial arrangement with three replications. experimental treatments were included soil nitrogen content (18, 50, 90, 200 and 3...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید