BACKGROUND Compound Danshen Tablet (CDT), a Traditional Chinese Medicine, has recently been reported to improve spatial cognition in a rat model of Alzheimer's disease. However, in vivo neuroprotective mechanism of the CDT in models of spatial memory impairment is not yet evaluated. The present study is aimed to elucidate the cellular mechanism of CDT on Aβ25-35-induced cognitive impairment in ...

A biomarker for alcoholism called Serum carbohydrate-deficient transferrin (CDT) is considered to be a reliable parameter reflecting long-term alcohol abuse (Stibler et al. 1988). It has been shown that CDT is not superior to other parameters previously identified (Scouller et al. 2000). CDT is also elevated in females suffering from psychiatric disorders inducing catabolism, limiting its diagn...

Article history: Received 26 May 2015 Accepted 27 July 2015 Available online 31 July 2015 Editor: L. Alvarez-Gaumé We study string field theory (third quantization) of the two-dimensional model of quantum geometry called generalized CDT (“causal dynamical triangulations”). Like in standard non-critical string theory the so-called string field Hamiltonian of generalized CDT can be associated wit...

Campylobacter jejuni encodes a cytolethal distending toxin (CDT) that causes cells to arrest in the G(2)/M transition phase of the cell cycle. Highly related toxins are also produced by other important bacterial pathogens. CDT activity requires the function of three genes: cdtA, cdtB, and cdtC. Recent studies have established that CdtB is the active subunit of CDT, exerting its effect as a nucl...

Serum carbohydrate-deficient transferrin (CDT) measurement is valuable for the identification of chronic excess alcohol consumption. CDT is increased in serum in approximately 50% of those classed as heavy drinkers and 70-80% of those defined as alcoholics. With abstinence, the serum CDT concentration reverts towards normal within approximately 2 weeks. Specificity for alcohol abuse ranges from...

Carbohydrate-deficient transferrin (CDT) is a useful indicator of excessive alcohol consumption with higher sensitivity and specificity than other markers that are used. In the present study, CDT was analysed in 161 patients hospitalized in a surgical ward to evaluate whether history of drinking and chronic alcohol misuse are important determinants of CDT elevations. Fifty-one of the patients w...

OBJECTIVE To investigate the effects of number of channels and speech-to-noise ratio on connected discourse tracking (CDT) through simulations of cochlear implant speech processing. Previous studies have used citation-form vowel and consonant materials or simple sentences. CDT rates were expected to be less likely to be limited by ceiling effects and more representative of everyday speech commu...

BACKGROUND The role of carbohydrate-deficient transferrin (CDT) as a reliable marker for the detection of chronic alcohol abuse has been discussed controversially. METHODS Therefore, we investigated CDT in the sera from 405 subjects with different alcohol intake. Besides healthy control subjects (n = 42), inpatients and outpatients in a department of gastroenterology (n = 325) and patients ad...

BACKGROUND Carbohydrate-deficient transferrin (CDT) is a useful biomarker to identify excessive alcohol consumption; however, few studies have validated the %CDT cut-off value in elderly men. This study estimated the optimal %CDT cut-off value that could identify excessive alcohol consumption in men aged ≥65 years. METHODS This retrospective study included 120 men who visited the department o...