Purpose: Calcium/calmodulin-dependent kinase II (CaMKII) is involved in the regulation of cell proliferation. Its endogenous inhibitor (hCaKIINa) is expressed in some cell types. We determined the role of CaMKII in RET-stimulated proliferation and hCaMKIINa in medullary thyroid carcinoma (MTC). Experimental Design: We analyzed the role of RET mutants on CaMKII activation in NIH3T3 and in MTC ce...

The genetic landscape of medullary thyroid cancer (MTC) is not yet fully understood, although some oncogenic mutations have been identified. To explore genetic profiles of MTCs, formalin-fixed, paraffin-embedded tumor tissues from MTC patients were assayed on the Ion AmpliSeq Cancer Panel v2. Eighty-four sporadic MTC samples and 36 paired normal thyroid tissues were successfully sequenced. We d...

Objective: This study investigates the behavior of two different radionuclide labels for liquid test meals and the stability of radionuclide labeling of solid meals. Methods: Technetium-99m DTPA and mTc colloid were compared as labels for liquid test meals in an in vivo investigation of gastric emptying rate. Half emptying time and retention percentages were used as parameters. Stability of sol...

OBJECTIVE We have previously reported that amylin/islet amyloid polypeptide (IAPP) mRNA is detected in a substantial subset of medullary carcinomas of the thyroid (MTCs). The aim of this study was to determine if the amylin/IAPP gene is expressed as the IAPP peptide in MTC tissues. DESIGN AND METHODS In 10 patients with a histological diagnosis of MTC and with persisting or recurrent disease ...

Machine-type communications (MTC) are a rapidly growing technology, which is expected to generate significant revenues to mobile network operators. In particular, smart grid is predicted to become one of the key MTC use cases that involves unattended meters autonomously reporting information to a grid infrastructure. With this research, we consider a typical smart metering MTC application scena...

Medullary thyroid carcinoma (MTC) is a rare tumor of the endocrine system with poor prognosis as it exhibits high resistance against conventional therapy. Recent studies have shown that monoclonal antibodies labeled with radionuclide have become important agents for diagnosing tumors. To elucidate whether single-chain fragment of variable (scFv) antibody labeled with 131I isotope is a potential...

Medullary thyroid carcinoma (MTC) is a rare malignancy that may metastasize to liver, lungs and bones. Breast is an unusual metastatic site for MTC and only 20 female cases have been reported in the literature. We present a male patient in whom histological examination and immunohistochemistry of a breast mass were indicative of breast metastasis from MTC. A 67-year-old man with recent diagnosi...

The familial risk of medullary thyroid carcinoma (MTC alone or as part of multiple endocrine neoplasms, MEN2A/MEN2B) is high, so we aimed to answer open questions about the lifetime cumulative risk of thyroid cancer (LCRTC at 0-79 years) among relatives of MTC patients by age and sex. For this nationwide study, a cohort of 3217 first-/second-degree relatives (FDRs/SDRs) of 389 MTC patients diag...

Simultaneous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in a single patient is an unusual event. The incidence, cell origin, histopathology features and prognosis of these two carcinomas are considered completely different. The aim of this retrospective study was to describe clinical, pathologic characteristics and the prevalence of diagnosing such pat...

A 60-year-old man who noted numbness and dyskinesia of his left-hand fingers was admitted to a hospital. After anticoagulant therapy and medication with L-3, 4-dihydroxyphenylalanine (L-DOPA) were started, his symptoms didn’t improve. He was introduced to our institution with gait disturbance and difficulty of articulating properly. L-DOPA was administered under a diagnosis of multiple system a...