considering the 50% mortality rate of neonatal septicemia associated with neutropenia and increasing resistance to antibiotics, simultaneous antibiotic therapy strategies are becoming more important. however, few studies have been performed to evaluate effectiveness of rhg-csf in the treatment of neutropenia in neonates. this randomized clinical trial was performed on 40 neutropenic neonates wi...

Background: In the present study, we hypothesized that conditioned medium (CM) derived from mesenchymal stem cells attenuates the brain oxidative stress in sepsis induced by the cecal ligation and puncture (CLP) model. Methods: This study was performed in the Department of Physiology at Tehran University of Medical Sciences from August 2018 to April 2019. Conditioned medium was collected from ...

differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. the aim of this study was to evaluate the ability of c-reactive protein (crp), erythrocyte sedimentation rate (esr), procalcitonin (pct), and interleukin-6 (il-6) to identify elderly patients with sepsis. in this single center prospective observational study, we included all consec...

abstract background: many people suffer from burn injuries every year, and burns make the patients undergo surgeries and years of rehabilitation. burns lead to more years of disability, compared to cancer or heart diseases. epidemiologic studies are needed to reveal the span, impact, and related factors of burns to help take appropriate efforts to reduce its mortality and morbidity. materials a...

conclusions respiratory distress is more common in eos whereas jaundice, fever and seizure are more likely to be observed in los infants. considering the results, clinical manifestations should be regarded as an important part of early diagnosis of sepsis. objectives the aim of this study was to evaluate, record and rank the clinical manifestations and lab data of neonates with clinical sepsis....

background objective: to evaluate the utility of specific cut-off values for c- reactive protein (crp) and immature-to-total neutrophil ratio (i/t) as screening tests for meningitis in culture negative early onset sepsis (eos). materials and methods retrospective chart review of 97 newborns with culture negative sepsis who had lumbar puncture performed as part of the sepsis evaluation in a leve...

conclusions due to the increasing resistance of pathogens to usual empirical antibiotics, it is reasonable to stress upon preventive measures, so that a minimum number of neonates develop sepsis. results coagulase-negative staphylococci (cons) were the most prevalent pathogens isolated from blood specimens in early and late-onset disease. escherichia coli and klebsiella were the most causative ...