ease. Nat Genet 38: 21–23, 2006 16. Nishio S, Tian X, Gallagher AR, Yu Z, Patel V, Igarashi P, Somlo S: Loss of oriented cell division does not initiate cyst formation. J Am Soc Nephrol 21: 295–302, 2010 17. Karner C, Wharton KA Jr, Carroll TJ: Planar cell polarity and vertebrate organogenesis. Semin Cell Dev Biol 17: 194–203, 2006 18. Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford ...

Previously, a series of clonal alloantigen-dependent T cell lines established from the channel catfish revealed distinctly different TCR beta rearrangements. Here, a follow-up study of the junctional diversity of these TCR gene rearrangements focuses on characterization of the genomic organization of the TCRB locus. Surprisingly, a total of 29 JB genes and two substantially different CB genes w...

Diosgenin, a steroidal saponin present in fenugreek (Trigonella foenum graecum) and other plants, has been shown to suppress inflammation, inhibit proliferation, and induce apoptosis in a variety of tumor cells, but through a mechanism that is poorly understood. In the present study, we report that diosgenin inhibits receptor-activated nuclear factor-kappaB ligand-induced osteoclastogenesis, su...

Viral infection or TLR3 engagement causes activation of the transcription factors IRF-3 and NF-jB, which collaborate to induce transcription of type I IFN genes. IKKe and TBK1 are two IKK-related kinases critically involved in virusand TLR3-triggered activation of IRF-3. We identified a protein termed SIKE (for Suppressor of IKKe) that interacts with IKKe and TBK1. SIKE is associated with TBK1 ...

doi: 10.1111/cas.12571 Breast cancer is a leading cause of cancer-related death in women. Prolonged exposure to the ovarian hormones estrogen and progesterone increases the risk of breast cancer. Although estrogen is known as a primary factor in mammary carcinogenesis, very few studies have investigated the role of progesterone. Receptor activator for nuclear factor-jB (NF-jB) ligand (RANKL) pl...

▼ Objectives: The purpose of this investigation was to evaluate whether Jobelyn ® (JB) possesses anti-depressant-like property in the mouse forced swimming test (FST), tail suspension test (TST) and yohimbine-induced lethality test (YLT) in aggregated mice. Methods: Mice were given JB (10–100 mg/kg, p.o.) daily for 7 days and then subjected to FST, TST, YLT and open fi eld test. The parameters ...

Living cells must be capable of rapidly responding to intrinsic and environmental cues to ensure normal development and homeostasis. The NF-jB transcription factor mediates a series of such rapid-response programs, serving as a master regulator of gene transcription in cells subjected to inflammation, irradiation, or other stress states (Karin, 2009). While cells must be able to rapidly respond...

Jordan C*-algebras go back to Kaplansky, see [20]. Let J be a complex Banach Jordan algebra, that is, a complex Banach space with commutative bilinear product x◦y satisfying x◦(x2◦y) = x2◦(x◦y) as well as ||x◦y|| ≤ ||x||·||y||, Bounded symmetric domains and generalized operator algebras 51 and suppose that on J is given a (conjugate linear) isometric algebra involution x 7→ x∗. Then J is called...

We consider deterministic and disordered frustrated systems in which we can show some strict inequalities with respect to related ferromagnetic systems. A case particularly interesting is the Edwards-Anderson spin-glass model in which it is possible to determine a region of uniqueness of the Gibbs measure, which is strictly larger than the region of uniqueness for the related ferromagnetic syst...

By exploiting his recent results, the author further investigates the extent to which variation in the coefficients of a unitary convex decomposition of a vector in a unital JB∗-algebra permits the vector decomposable as convex combination of fewer unitaries; certain C∗-algebra results due to M. Rørdam have been extended to the general setting of JB∗-algebras.