Tropomyosin (TM) is an integral component of the thin filament in muscle fibers and is involved in regulating actin-myosin interactions. TM is encoded by a family of four alternatively spliced genes that display highly conserved nucleotide and amino acid sequences. To assess the functional and developmental significance of a-TM, the murine a-TM gene was disrupted by homologous recombination. Ho...

PURPOSE Loss or dysfunction of trabecular meshwork (TM) cells has been associated with the development of pathologically elevated IOP, and it is conceivable that replacement of damaged TM cells could restore function to the TM. We propose that the use of TM-like cells derived from induced pluripotent stem cells (iPSCs) created from a patient's own dermal fibroblasts offers the best solution to ...

It has been revealed that the function of transmembrane (TM) proteins (20-30% in most genomes [1]) can be classified and identified with the information of its TM topologies, i.e., the number of TM segments (TMSs), the position of TMS and the orientation of the TMS to the membrane lipid bilayer [6]. Therefore, developing the TM topology prediction method with high reliability is critical task f...

The purpose of this study was to investigate whether the practice of the Transcendental Meditation (TM) and TM-Sidhi program influences cognitive-moral development. Seventy-six undergraduate students, ranging in age from 16 to 23 years, participated in the study: I7 students from Roger Williams College, Rhode Island, who were not predisposed to starting the TM program (nonmeditators); I2 studen...

Previous reports demonstrated that the expression of thrombomodulin (TM) in endothelial cells was modulated by various agents. Although TM was down-regulated by endotoxin or cytokines, up-regulation of TM was accomplished when endothelial cells were stimulated with unphysiologically high concentrations of cyclic AMP derivatives or tumour-promoting phorbol esters. We investigated the expression ...