Differentiation therapy based on all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) for the treatment of acute promyelocytic leukemia (APL) is complicated by the development of differentiation syndrome (DS), which can be fatal. We examined the role of HMGB1 (high-mobility group box 1) in DS using both in vitro and in vivo models. HMGB1 and the pro-inflammatory cytokines IL-1β and TNF-α w...

Idarubicin (IDR), cytarabine (AraC), and tamibarotene (Am80) are effective for treatment of acute myeloid leukemia (AML). In acute leukemia, the incidence of venous thromboembolism or disseminated intravascular coagulation is associated with induction chemotherapy. Procoagulant effects of IDR, AraC, and Am80 were investigated in a vascular endothelial cell line EAhy926 and AML cell lines HL60 (...

The acute promyelocytic leukemia cell line NB4 was differentiated by all-trans retinoic acid (ATRA), which enhanced the superoxide-producing capacity stimulated by the chemotactic peptide and phorbol ester in this cell line. Granulocyte colony-stimulating factor (G-CSF) by itself had no effect on NB4 cells but exerted additional enhancing effects on the respiratory burst activity in the presenc...

Bactericidal/permeability-increasing protein (BPI) neutralizes the proinflammatory effects of lipopolysaccharide and is of potential clinical use in the treatment of fulminant Gram-negative infections. BPI is a cationic protein with antibacterial activity stored in azurophil (primary) granules of neutrophil granulocytes. However, the absence of BPI in patients with specific granule deficiency i...

هدف: هدف پژوهش حاضر، ساخت و اعتبار­سنجی سیاهه آسیب‌شناسی روانشناختی نوجوانان در فضای مجازی بود. روش: روش آمیخته اکتشافی (کیفی-کمی) بدین منظور با استفاده از تحلیل مضمون مقالات مصاحبه‌های انجام‌شده متخصصان فعال مجازی، آسیب­ ها شناسایی شدند بر اساس آن ­ای ساخته شد. جامعه آماری بخش کیفی شامل مقالات، اساتید دانشگاه­ های اراک، اصفهان، امام خمینی قزوین شهر اراک بودند که نمونه هدفمند آنها انتخاب کمی بو...

A determining role has been assigned to cAMP in the signaling pathways that relieve resistance to anti-leukemia differentiation therapy. However, the underlying mechanisms have not been elucidated yet. Here, we identify cFos as a critical cAMP effector, able to regulate the re-expression and splicing of epigenetically silenced genes associated with maturation (CD44) in retinoid-resistant NB4-LR...

انتقال ویروس کرونا به داخل سلول از طریق اسپایک‌های انجام می‌شود پس یکی بهترین راه‌های مقابله با سلول‌های بدن، ایجاد اختلال در روند عملکرد است. بنابراین این تحقیق، چگونگی جذب و انرژی پرتوهای رادیواکتیو سارس کووید2، مرس کووید، یوکی کووید توسط ابزار جینت4- دی اِن اِی شبیه‌سازی شده نتایج حاصل پرتودهی اسپایک‌ها یکدیگر مقایسه آن‌جایی که عوامل کاهش ماندگاری می‌باشد، پژوهش سعی است اسپایک ویروس­‌ها به‌وسی...

Dysregulated expression of miRNAs can play a vital role in pathogenesis of leukemia. The shortened telomere length, and elevated telomerase activity in acute promyelocytic leukemia cells are mainly indicative of extensive proliferative activity. This study aimed to investigate the effect of overexpression of miR-138 on telomerase activity, and cell proliferation of acute promyelocytic leukemia ...

Objective: Cuscuta campestris or common dodder is a holoparasitic  plant  that  has  been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of C. campestris had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydr...