نتایج جستجو برای: سازۀ pbc
تعداد نتایج: 1894 فیلتر نتایج به سال:
There is substantial data that suggests an abnormality of innate immunity in patients with primary biliary cholangitis (PBC) which includes the transcription factor nuclear factor-kB (NF-kB) and well as downstream inflammatory signaling pathways. In addition, ImmunoChip analysis has identified a novel PBC-associated locus near the receptor activator of NF-kB ligand (RANKL) gene. Based on these ...
INTRODUCTION Primary biliary cirrhosis (PBC) is an autoimmune liver disease with approximately 50% of patients experiencing fatigue. This can be a particularly debilitating symptom, affecting quality of life and resulting in social isolation. Fatigue is highlighted by patients as a priority for research and patient support groups were involved in designing this trial. This is the first randomis...
P rimary biliary cirrhosis (PBC) is an autoimmune disease of the liver characterized by the presence of highly specific antimitochondrial antibodies with resulting immune-mediated injury of small intrahepatic bile ducts. Palmoplantar keratodermas (PPKs) are characterized by hyperkeratosis of the skin on the palms and soles. Multiple cases have been reported associating PPK with autoimmune thyro...
The Petri Box Calculus (PBC) combines two well known paradigms of the design of concurrent systems: process algebras and Petri nets. In our first proposal of sPBC (stochastic PBC) [12] we defined a Markovian extension of finite PBC, i.e., we had a Markovian process algebra for which both an operational and a denotational (based on stochastic Petri nets) semantics were defined. Our goal in this ...
Recently, there is ample evidence suggesting the important role of microRNAs (miRNAs) in autoimmune diseases via modulating B cells function. Primary biliary cholangitis (PBC) is a progressive immune-mediated liver disease with unclear pathogenic mechanism. Whether the miRNA in peripheral B cells of PBC involve the mechanisms of pathology and progression is not known. The present study explores...
We studied nondiagnostic liver biopsy specimens from 20 patients with definite primary biliary cirrhosis (PBC) and 18 with definite autoimmune hepatitis (AIH) to identify distinguishing features. All patients had early-stage disease; biopsy specimens were devoid of granulomas or diagnostic features of PBC or AIH. Diagnoses were based on serologic and clinical variables. Sixteen specimens from e...
Lymphocyte subpopulations were measured in the peripheral blood of 13 patients with primary biliary cirrhosis (PBC), 13 with chronic active hepatitis (CAH), and 16 age- and sex-matched normal subjects. A significant, relative and absolute, reduction in activated T cells and K cells, compared with that in normal subjects, was found in PBC but not in CAH. The reduction in K cells observed in PBC ...
The association between primary biliary cirrhosis (PBC) and cutaneous vasculitides is well recognized. Pustular skin lesions though, have been described in association with hepatobiliary diseases other than PBC. Once the more common infective pustular rashes have been excluded, the differential diagnoses for a pustular skin rash are acute generalized exanthematous pustulosis (AGEP), Sweet's Syn...
Primary Biliary Cirrhosis (PBC) and Autoimmune Hepatitis (AIH) may simultaneously coexist in some patients, designated as PBC-AIH overlap syndrome. Acute hepatic failure is an unusual initial form of presentation of PBCAIH overlap syndrome. We report the case of a 31 year-old woman with autoimmune PBC-AIH overlap syndrome who presented with an acute hepatic failure. She revealed a good response...
BACKGROUND/AIM Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis in chronic cholestatic conditions: primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). MATERIALS/METHODS Western-blot/PCRs for SULT2A1/PXR were performed ...
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