BACKGROUND hCG is a term referring to 4 independent molecules, each produced by separate cells and each having completely separate functions. These are hCG produced by villous syncytiotrophoblast cells, hyperglycosylated hCG produced by cytotrophoblast cells, free beta-subunit made by multiple primary non-trophoblastic malignancies, and pituitary hCG made by the gonadotrope cells of the anterio...

BACKGROUND Pathological examination combined with tumor markers has become a standard for the diagnosis of intracranial germ cell tumors (ICGCTs), but the current concept of 'secreting germ cell tumors' and three empirically highly specific diagnostic criteria (β-hCG ≥ 50 IU/L or αFP ≥ 10 ng/mL; β-hCG ≥ 100 IU/L or αFP ≥ 50 ng/mL; β-hCG > 50 IU/L or αFP > 25 ng/mL) are not based upon pathology ...

Introduction: The diagnosis of pregnancy from forensic bloodstains can be useful in cases infanticide, criminal abortions and missing person identification. Objective: This research illustrated the use a rapid, precise, tremendously responsive enzyme immunoassay kit designed for medical usage, which is put to good our lab qualitative HCG detection blood stains has proven tool Methods: concentra...

48075, in which the 2nd International Standard for HCG is used. This colorimetric method is ideally suited for the small laboratory because of its simplicity and minimal equipment requirements. Essentially, the test is a solid-phase IEM involving pelystyrene tubes coated with anti-HCG (monoclonal mouse IgG). The serum HCG is “sandwiched” (1) by the solid-phase HCG enzymelabeled antibody at room...

Measurement of serum human chorionic gonadotropin (HCG) concentration is a standard method to detect pregnancies after in vitro fertilization (IVF). Radio immune assay or for HCG targeting the specific beta subunit of HCG dimer was established more than 30 years ago [1,2]. Today, more advanced assay methods are widely used in many medical institutes. While transvaginal ultrasound can detect pre...

The effect of human chorionic gonadotropin (hCG) on the rabbit eye was studied. Intravitreal injections of hCG in albino rabbits provoked a reduction of intraocular pressure (IOP). Intravenous administration of hCG in single doses of 5,000-10,000 units in male pigmented rabbits caused a significant reduction in IOP from 1.5-5 hr after injection. When two successive intravenous doses of 5,000 un...

BACKGROUND Serum human chorionic gonadotropin (hCG) and hCG free beta-subunit tests are used in combination with unconjugated estriol and alpha-fetoprotein in the triple screen test, and with the addition of inhibin-A in the quadruple marker test for detecting Down syndrome in the second trimester of pregnancy. These tests have a limited detection rate for Down syndrome: approximately 40% for h...

BACKGROUND Successful embryo implantation depends on a well-timed maternal-embryonic crosstalk. Human chorionic gonadotropin (hCG) secreted by the embryo is known to play a key role in this process and to trigger a complex signal transduction cascade allowing the apposition, attachment, and invasion of the embryo into the decidualized uterus. Production of hCG was reported to be dependent on bl...

A specific and sensitive radioimmunoassay for human choriogonadotropin (hCG) has been developed using rabbit antiserum to chemical analogs of beta subunit of human chorionic gonadotropin prepared by controlled reduction and S-alkylation of its disulfide linkages. The assay was highly specific for hCG as the binding of [125I]-hCG to the antibody was not affected by standard human lutropin, by hu...

The nanogold reaction between HAuCl4 and citrate is very slow, and the catalyst graphene oxide nanoribbon (GONR) enhanced the nanoreaction greatly to produce gold nanoparticles (AuNPs) that exhibited strong surface plasmon resonance (SPR) absorption (Abs) at 550 nm and resonance Rayleigh scattering (RRS) at 550 nm. Upon addition of the peptide of human chorionic gonadotropin (hCG), the peptide ...