Sequential to parallel program transformation is an approach to parallel systems development which removes some of the disadvantages of parallelising compilers and parallel programming. 4P is a suitable paradigm for such transformations. The transformation system accepts a sequential program, performs partial automatic transformation, and then interacts with the user to generate the correspondi...

A theoretical study of interaction of ethylene with Cuz is considered using SCF/CASSCF/MP2 methods. The calculated dissociation energy is in good agreement with available experimental data. Our studies reveal that the perpendicular approach of Cu2 is more favored than the parallel approach. The strong bonding is assisted through the donation of x-electronic density from ethylene to the 4p orbit...

Doolen, Suzanne, Diana N. Krause, and Sue P. Duckles. Estradiol modulates vascular response to melatonin in rat caudal artery. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1281–H1288, 1999.—The purpose of this study was to determine whether estrogen modulates the function of vascular melatonin receptors. We used the rat caudal artery and found that the contractile effects of melatonin were i...

Protein import to the nucleus is a signal-mediated process that exhibits saturation kinetics. We investigated whether signal bearing proteins compete with U2 and U6 snRNPs during import. When injected into Xenopus oocytes, saturating concentrations of P(Lys)-BSA, a protein bearing multiple nuclear localization signals from SV40 large T-antigen, reduce the rate of [125I]P(Lys)-BSA and of [125I]n...

In the excitation spectrum of KC1 :Cuthe A band due to 'A,,(4s2) + 3Tlu(4s 4p) is detected. Its flat-topped shape reveals equal coupling to e, and tZg modes, whereas the near-gaussian shape of the C band signifies preponderant coupling of the ITlu state to the t2, mode. Negligible quadratic coupling is deduced from a moment analysis of several C bands. A newly detected absorption band in the D ...

The kink-turn (k-turn), a new RNA structural motif found in the spliceosome and the ribosome, serves as a specific protein recognition element and as a structural building block. While the structure of the spliceosomal U4 snRNA k-turn/15.5K complex is known from a crystal structure, it is unclear whether the k-turn also exists in this folded conformation in the free U4 snRNA. Thus, we investiga...

In large ribonucleoprotein machines, such as ribosomes and spliceosomes, RNA functions as an assembly scaffold as well as a critical catalytic component. Protein binding to the RNA scaffold can induce structural changes, which in turn modulate subsequent binding of other components. The spliceosomal U4/U6 di-snRNP contains extensively base paired U4 and U6 snRNAs, Snu13, Prp31, Prp3 and Prp4, s...

In the study of cellular RNA chemistry, a major thrust of research focused upon sequence determinations for decades. Structures of snRNAs (4.5S RNA I (Alu), U1, U2, U3, U4, U5, and U6) were determined at Baylor College of Medicine, Houston, Tex, in an earlier time of pregenomic era. They show novel modifications including base methylation, sugar methylation, 5'-cap structures (types 0-III) and ...

A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily.