Purpose : Only a few studies on diffusion weighted (DW) imaging of ovarian lesions have been reported (1-3). In previous studies, the role of DW imaging in distinguishing between benign and malignant cystic tumors may be limited. Katayama et al (3) reported that apparent diffusion coefficient (ADC) values may not provide additional information, especially to discriminate benign from malignant l...

OBJECTIVES Primary cervical screening uses cytology to detect cancer precursor lesions [cervical intraepithelial neoplasia stage 3 or beyond (CIN3+)]. Human papillomavirus (HPV) testing could add sensitivity as an adjunct to cytology or as a first test, reserving cytology for HPV-positive women. This study addresses the questions: Does the combination of cytology and HPV testing achieve a reduc...

The transmission of cellular signals often proceeds through multiprotein complexes where enzymes are positioned in proximity to their upstream activators and downstream substrates. In this report we demonstrate that the A-kinase anchoring protein AKAP-Lbc assembles an activation complex for the lipid-dependent enzyme protein kinase D (PKD). Using a combination of biochemical, enzymatic, and imm...

Heart failure is a lethal disease that can develop after myocardial infarction, hypertension, or anticancer therapy. In the damaged heart, loss of function is mainly due to cardiomyocyte death and associated cardiac remodeling and fibrosis. In this context, A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that facilitate the spatiotemporal activation of the cyclic...

Abstract In China, rural children, compared to their urban counterparts, are disadvantaged by less parental care and limited access educational resources. This can have dire consequences for health-related well-being during a vulnerable formative stage of the life course. Quality (QOL) has been increasingly used as an indicator individuals’ well-being. QOL studies primarily conducted in Western...

Abstract Background: Some countries have implemented stand-alone human papillomavirus (HPV) testing while others consider cotesting for cervical cancer screening. We compared both strategies within a population-based study. Methods: The MARZY cohort study was conducted in Germany. Randomly selected women from population registries aged ?30 years (n = 5,275) were invited to screening with Pap sm...

◊ Department of Biochemistry, University of British Columbia, 2146 Health Science Mall, Vancouver, British Columbia, V6T 1Z3 ‡ CIHR Membrane Protein Research Group, Department of Biochemistry, 474 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7. ¶ Laboratoire de Chimie Bactérienne, CNRS, 31 chemin Joseph Aiguier, 13402 Marseille Cedex 9, France + UMR6191, LBC, CEA Ca...

Postila, Pekka Dynamics of the ligand-binding domains of ionotropic glutamate receptors. Jyväskylä: University of Jyväskylä, 2010, 54 p. (Jyväskylä Studies in Biological and Environmental Science, ISSN 1456-9701; 214) ISBN 978-951-39-4182-6 (PDF), 978-951-39-4081-2 (nid.) Yhteenveto: Ionotrooppisten glutamaattireseptoreiden ligandinsitomisdomeenien dynamiikka. Diss. Ionotropic glutamate recepto...