The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

I apologize both to Jane Fountain and to my fellow workshop participants for the lateness of this memo, which reflects both an overwrought end-of-semester schedule and a certain diffidence stemming from my lack of expertise in the topic of the workshop. My own empirical research on digital technologies has dealt with how typical Americans – that is, the cross-section of folks that a well design...

The health care environment was once regarded as safe and secure for patients and staff. Turmoil and change have pervaded the U.S. health care system since the 1980s, contributing to a state of chaos and instability. Today’s health care work environment can therefore be characterized as turbulent—it is in a state of unrest, disturbance, agitation, or commotion. There are many sources of turbule...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

The goal of this study was to provide a reasonable assessment of how probe substrate selection may impact the results of in vitro aldehyde oxidase (AO) inhibition experiments. Here, we used a previously studied set of seven known AO inhibitors to probe the inhibition profile of a pharmacologically relevant substrate N-[(2dimethylamino)ethyl]acridine-4-carboxamide (DACA). DACA oxidation in human...

Numerous studies have demonstrated a correlation of matrix metalloproteinase (MMP) overexpression with the prognosis of various kinds of cancer. The current study investigated whether the expression of MMPs is correlated with the prognosis of osteosarcoma. Expression levels of MMP-2, -9, MT1-MMP and TIMP-2 were examined immunohistochemically in samples from 47 patients with osteosarcoma. Correl...

incidence of adolescent pregnancy.3 Access to contraceptives has become increasingly crucial for adolescents because many are sexually active at earlier ages than in the past. During the mid-to-late 1950s, 8% of adolescent females had had intercourse by age 16. In contrast, by the early-to-mid–1980s, 21% of female teenagers had had sex by age 16. Among all adolescents in the 1990s, 50% had sex ...