INTRODUCTION The growing problem of antibacterial resistance resulted in an increased interest in fosfomycin, especially its parenteral formulation. We reviewed fosfomycin safety profile using the Food and Drug Administration Adverse Event (AE) Reporting System (FAERS) and published literature. METHODS We conducted a FAERS search and disproportionality analysis of all fosfomycin-associated AE...

Differential fault attack (DFA) is a distinctive methodology for acquiring the key to block ciphers, which comprises two distinct strategies: DFA on state and schedule. Given widespread adoption of Advanced Encryption Standard (AES), it has emerged as prominent target DFA. This paper presents an efficient AES, utilizing two−byte model that induces faults at with discontiguous rows. The experime...

OBJECTIVES To characterize risk factors for occurrence of adverse events (AEs) and treatment discontinuations due to AEs for improving safety and tolerability of treatment of postherpetic neuralgia (PHN). METHODS Patients with PHN (n=556) received 1800 mg once-daily gastroretentive gabapentin (G-GR) in 2 phase 3 and 1 phase 4 study. Safety assessments included the incidence and severity of AE...

The human Transducin-like Enhancer of Split (TLE) and mouse homologue, Groucho gene-related protein (GRG), represent a family of conserved non-DNA binding transcriptional modulatory proteins divided into two subgroups based upon size. The long TLE/GRGs consist of four pentadomain proteins that are dedicated co-repressors for multiple transcription factors (TF). The second TLE/GRG subgroup is co...

One difficulty in the cryptanalysis of the Advanced Encryption Standard AES is the tension between operations in the two fields GF (2) and GF (2). This paper outlines a new approach that avoids this conflict. We define a new block cipher, the BES, that uses only simple algebraic operations in GF (2). Yet the AES can be regarded as being identical to the BES with a restricted message space and k...

While the AES algorithm is regarded as secure, many implementations of AES are prone to cache side-channel attacks. The lookup tables traditionally used in AES implementations for storing precomputed results provide speedup for encryption and decryption. How such lookup tables are used is known to affect the vulnerability to side channels, but the concrete effects in actual AES implementations ...

PURPOSE Anti-programmed cell death receptor-1 (PD-1) antibodies have demonstrated antitumor activity in many cancer entities. Hepatic adverse events (AEs) are one of its major side effects, but the overall risks have not been systematically evaluated. Thus, we conducted this meta-analysis to investigate the overall incidence and risk of developing hepatic AEs in cancer patients treated with PD-...

BACKGROUND The MacArthur Admission Experience Survey (AES) is a widely used tool to evaluate the level of perceived coercion experienced at psychiatric hospital admission. The French-language AES was prepared using a translation/back-translation procedure. It consists of 16 items and 3 subscores (perceived coercion, negative pressures and voice). This study aimed to assess the psychometric prop...

OBJECTIVE This study determined the incidence, type, nature, preventability and impact of adverse events (AEs) among hospitalised patients and potentially preventable deaths in Dutch hospitals. METHODS Using a three-stage retrospective record review process, trained nurses and doctors reviewed 7926 admissions: 3983 admissions of deceased hospital patients and 3943 admissions of discharged pat...

BACKGROUND In randomized clinical trials, adverse events (AEs) are reported for the drug under evaluation and compared with the placebo group. Patients who receive placebo treatment report a high frequency of AEs, but little is understood about the nature of these. No study has yet analyzed the level of cognitive impairment as a crucial aspect for the AEs reported by patients. METHODS The rat...