Clinically used somatostatin (SRIF) analogs, octreotide and lanreotide, act primarily by binding to SRIF receptor subtype 2 (sst2). In contrast, the recently described multiligand SOM230 binds with high affinity to sst(1-3) and sst5 and KE 108 is characterised as a high affinity ligand for all five SRIF receptors. In tumoural mouse corticotrophs (AtT-20 cells) and in mouse hippocampus, binding ...

By designing optimal administration schedules, it was found that 4-carbamoylimidazolium 5-olate (SM-108) showed an excellent antitumor potency against a number of murine tumors. The optimal administration schedule of SM-108 was an intermittent multiple administration, in which the drug was multiply administered to mice at definite intervals of less than 3 hr for about 1 day on Days 1, 5, and 9 ...

Apoptotic cells generated by programmed cell death are engulfed by phagocytes and enclosed within plasma membrane-derived phagosomes. Maturation of phagosomes involves a series of membrane-remodeling events that are governed by the sequential actions of Rab GTPases and lead to formation of phagolysosomes, where cell corpses are degraded. Here we identified gop-1 as a novel regulator of apoptoti...

The role of the C-terminal region of adrenodoxin was studied by analyzing deletion mutants 4-114 and 4-108 lacking amino acids 1-3 and 115-128 or 109-128, respectively. Absorption spectra of these mutants were found to be identical to that of wild type adrenodoxin. However, EPR and CD studies indicated that the structure of deletion mutants 4-114 and 4-108 differs from that of wild type adrenod...

Links [1] http://www.sba.unipi.it/it/sba/organizzazione/segreteria-amministrativa [2] http://www.sba.unipi.it/it/sba/personale/tacchi-franca [3] mailto:franca&# 46;tacchi@sba.un&#105 ;pi.it [4] http://www.sba.unipi.it/it/sba/personale/bertela-pier-carla [...

The activities of six bacteriophage T2r+-induced enzymes (thymidylate synthetase, deoxycytidylate deaminase, thymidylate kinase, deoxycytidylate hydroxymethylase, deoxycytidine pyrophosphatase, and dihydrofolate reductase) were measured after dilution of phage-infected Escherichia coli B from 8 X 108 to 2 x 108 cells per ml. The only enzyme activity altered was that of deoxycytidylate deaminase...

Links [1] http://www.sba.unipi.it/it/sba/organizzazione/segreteria-amministrativa [2] http://www.sba.unipi.it/it/sba/personale/tacchi-franca [3] mailto:franca&# 46;tacchi@sba.un&#105 ;pi.it [4] http://www.sba.unipi.it/it/sba/personale/bertela-pier-carla [...

Links [1] http://www.sba.unipi.it/it/sba/organizzazione/segreteria-amministrativa [2] http://www.sba.unipi.it/it/sba/personale/tacchi-franca [3] mailto:franca&# 46;tacchi@sba.un&#105 ;pi.it [4] http://www.sba.unipi.it/it/sba/personale/bertela-pier-carla [...

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