This study evaluated the toxicological effect of oral administration Phoenix dactylifera seed essential oil (PDEO) in Wistar rats. PDEO was extracted through a steam-distillation technique. Acute toxicity single dose group (n = 5) rats followed by 24 h observation, for sub-acute evaluation, animals were randomly divided into five groups 3). Group 1 to 4 rats, respectively, received 62.5, 125, 2...