This paper introduces an approach for highly efficient simulation of supply networks in which several nodes use advanced planning and scheduling (APS) systems. APS systems increasingly become part of bigger companies IT landscape. Today, APS systems communicate only with the ERP system they sit on top of. If APS systems would be able to communicate with each other, qualitatively new processes f...

Introduction Antiphospholipid syndrome (APS) is characterized by venous or arterial thrombosis and/or fetal losses, in the presence of one or more types of antiphospholipid antibodies (aPL) (Anitcardiolipin antibodies (ACA), lupus anticoagulant (LA) or anti beta 2-glycoprotein I (b2GPI). Information about APS in juvenile patients is limited and reports showed some differences between the clinic...

The antiphospholipid syndrome (APS) defines the clinical association between antiphospholipid antibodies and a syndrome of hypercoagulability or thrombophilia (the term of "sticky blood" is sometimes used in APS). Antiphospholipid antibodies comprise a broad family of antibodies including both lupus anticoagulants and anticardiolipin antibodies. The pathogenesis of APS remains unclear. Neverthe...

BACKGROUND Catastrophic antiphospholipid syndrome (APS) is defined as life threatening multiple organ thromboses developing simultaneously or over a short period. The survival rate of catastrophic APS is about 50%, but the long term outcome of patients who survive is unknown. OBJECTIVE To determine the long term outcome of patients with catastrophic APS and provide further information on pati...

Detrusor smooth muscle (DSM) contributes to bladder wall tension during filling, and bladder wall deformation affects the signaling system that leads to urgency. The length-passive tension (L-T(p)) relationship in rabbit DSM can adapt with length changes over time and exhibits adjustable passive stiffness (APS) characterized by a L-T(p) curve that is a function of both activation and strain his...

Purpose The purpose is to find out which factors, during APS implementations, that affects the effects of the implementation. Methodology A multiple case study is conducted where Critical Success Factors (CSFs) from ERP literature and effects from APS implementations are studied. Findings Findings show that several ERP CSFs most likely are applicable in APS implementations. Practical implicatio...

Polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai act as potent anticholinesterase agents; in addition they show moderate hemolytic and cytotoxic activities. The hemolytic activity of poly-APS is due to their detergent-like structure and behavior in aqueous solutions. In this work, the hemolytic activity of poly-APS is analyzed and compared to that of stru...