Mice with the X-chromosomal sparse-fur (spf) mutation frequently have urinary bladder stones composed mostly of orotic acid, which was identified by the following criteria: ultraviolet and infrared absorption, spectra, chromatographic behavior, melting point, and reactivity in a specific color test. This clue led to the discovery that spf-bearing mice have an abnormal form of liver ornithine ca...

Abstract. The titanium alloy hollow lattice structures can be widely applied on the advanced aircrafts due to their excellent mechanical properties and light weight. Superplastic forming diffusion bonding (SPF/DB) process is an manufacture these with two outer plates one inner plate. To further decrease weight of structures, thinner plate preferred when compared plate, however, it would result ...

In order to obtain a description of the hydrographic state of the North Atlantic Current-Subpolar Front (NAC-SPF) system, historical hydrographic data from the subpolar North Atlantic are projected into a baroclinic stream function space, resulting in three dimensional gravest empirical mode (GEM) fields for temperature and specific volume anomaly, parameterized by pressure, dynamic height, and...

Using a case control approach, we performed a two-way comparison study between GP5+/6+-PCR and HPV SPF(10)-Line Blot 25 (SPF(10)) assays for detection of 14 types of high-risk human papillomavirus (hrHPV) in samples from women with normal cytology results who had or developed grade 3 cervical intraepithelial neoplasia (CIN 3). Samples were pooled from two cohorts, i.e., women participating in p...

BACKGROUND The liver is the central organ for xenobiotic metabolism (XM) and is regulated by nuclear receptors such as CAR and PXR, which control the metabolism of drugs. Here we report that gut microbiota influences liver gene expression and alters xenobiotic metabolism in animals exposed to barbiturates. PRINCIPAL FINDINGS By comparing hepatic gene expression on microarrays from germfree (G...

Noroviruses cause most cases of acute viral gastroenteritis worldwide. The lack of a cell culture infection model for human norovirus necessitates the use of molecular methods and/or viral surrogate models amenable to cell culture to predict norovirus inactivation. Murine norovirus (MNV) may be used to construct a small animal model for studying the biology and pathogenesis of noroviruses becau...