The transporter associated with antigen processing (TAP) plays a key role in adaptive immunity by translocating proteasomal degradation products from the cytosol into the endoplasmic reticulum lumen for subsequent loading onto major histocompatibility (MHC) class I molecules. For functional and structural analysis of this ATP-binding cassette complex, we established the overexpression of TAP in...

We investigated the biochemical and immunological characteristics of teichoic acid preparations (TAP) obtained from four unencapsulated strains of Staphylococcus aureus which nonetheless, according to the serum-soft agar technique, produced capsular type antigen and were representative of the four types A, B, C, and D. In the agar diffusion test, TAP of each strain produced a single precipitin ...

objective: considering the use of triple antibiotic paste (tap) for root canal treatment of open apex teeth, this study aimed to assess the effect of tap and calcium hydroxide (ch) on bond strength of composite to dentin.   methods: this in-vitro study was conducted on 32 extracted human premolar teeth. after disinfection with 2% thymol solution, the enamel on the buccal surface of specimens wa...

INTRODUCTION We conducted a single-centre, prospective randomised clinical trial to investigate the analgesic efficacy of transversus abdominis plane (TAP) block in adult patients undergoing laparoscopic appendicectomy. METHODS Patients undergoing urgent laparoscopic appendicectomy under general anaesthesia alone (control group) and general anaesthesia supplemented by TAP block (TAP intervent...

Detection and elimination of virus-infected cells by cytotoxic T lymphocytes depends on recognition of virus-derived peptides presented by MHC class I molecules. A critical step in this process is the translocation of peptides from the cytoplasm into the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Here, we identified the bovine herpesvirus 1-encoded UL49.5...

PURPOSE Transversus abdominis plane (TAP) block is a newly developed and effective peripheral block involving the nerves of the anterior abdominal wall for lower abdominal surgery. We evaluated the postoperative analgesic efficacy of ultrasound-guided TAP block using 20 mL of 0.5% levobupivacaine in patients undergoing open appendectomy. METHODS Forty-four patients undergoing appendectomy wer...

Received: 24 Nov 2014 Accepted: 12 May 2015 Abstract Background and Aim: Some researchers have attempted to enhance the antibacterial properties of sealers by addition of antibiotics while this may affect their physical properties. The purpose of this in vitro study was to compare the working time and flow of AH Plus sealer alone and in combination with amoxicillin and triple antibiotic paste (...

OBJECTIVE Therapeutic anticoagulation is widely used, but limitations in efficacy and bleeding complications cause an ongoing search for new agents. However, with new agents developed it seems to be an inherent problem that increased efficiency is accompanied by an increase in bleeding complications. We investigate whether targeting of anticoagulants to activated platelets provides a means to o...

In human cells the association of MHC class I molecules with TAP is thought to be mediated by a third protein termed tapasin. We now show that tapasin is present in murine TAP-class I complexes as well. Furthermore, we demonstrate that a mutant H-2Dd molecule that does not interact with TAP due to a Glu to Lys mutation at residue 222 of the H chain (Dd(E222K)) also fails to bind to tapasin. Thi...

We develop a TAP mean eld approach to models with quadratic interactions which does not assume a speciic randomness of the couplings but rather adapts to the concrete data. The method is based on an extra set of mean eld equations for the Onsager correction term to the naive mean eld result. We present applications for the Hoppeld model and for a Bayesian classiier. 1.1 Introduction Mean eld (M...