Previous studies have shown that pre-treatment of Escherichia coli B23 with subinhibitory concentrations of aminoglycosides leads to a subsequent increase in the level of capsular polysaccharide, as well as an increased resistance to streptomycin. Using capsular polysaccharide synthesis pathway mutants, we investigated the correlation between the level of capsular polysaccharide and streptomyci...

The acridinone derivates 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8hydroxyimidazoacridinone (C-1311) are promising antitumor agents with high activity against several experimental cellular and tumor models and are under evaluation in preclinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both comp...

– We analyzed skins and skulls of chevrotains (Moschiola sp., Artiodactyla) from Sri Lanka and India, and found considerable differences within this taxon. Based on the consistency of these differences we concluded that this taxon can be divided into three species: Moschiola indica from southern India, M. meminna from the Dry Zone in Sri Lanka, and M. kathygre n. sp. from Sri Lanka’s Wet Zone. ...

Age-related macular degeneration (AMD) is a complex neurodegenerative visual disorder that causes profound physical and psychosocial effects.Visual impairment inAMD is causedby the lossof retinal pigmented epithelium (RPE) cells and the light-sensitive photoreceptor cells that they support. There is currently no effective treatment for the most common form of this disease (dry AMD). A new appro...

The nucleolus is a subnuclear compartment and the site of ribosome biogenesis. Previous studies have implicated protein ubiquitylation in nucleolar activity. Here we show that USP36, a deubiquitylating enzyme of unknown function, regulates nucleolar activity in mammalian cells. USP36 localized to nucleoli via the C-terminal region, which contains basic amino acid stretches. Dominant-negative in...

MicroRNAs might act as oncogenes or tumor suppressors in cancer. Recent studies have shown that miR-421 is up-regulated in human gastric cancer. Here, we found that miR-421 was over-expressed in gastric cancer tissues and cell lines. Bioinformatics analysis predicted that the caspase-3 gene was a target of miR-421. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level....