In this paper, the authors present a linear matrix inequality (LMI) approach to the strictly positive real (SPR) synthesis problem: find an output feedback K such that the closed-loop system T (s) is SPR. The authors establish that if no such constant output feedback K exists, then no dynamic output feedback with a proper transfer matrix exists to make the closed-loop system SPR. The existence ...

The combined use of surface plasmon resonance (SPR) and modified or mimic oligonucleotides have expanded diagnostic capabilities of SPR-based biosensors and have allowed detailed studies of molecular recognition processes. This review summarizes the most significant advances made in this area over the past 15 years.   Functional and conformationally restricted DNA analogs (e.g., aptamers an...

Polarization-contrast microscopy coupled with an atomic force microscope is utilized to attain far-field optical images of the multipolar surface plasmon resonance (SPR) modes of single gold nano-rod. Modulated standing modes resulted from the interference of longitudinal SPR modes and incident light are observed and studied. By counting the average distance of adjacent beats on this single gol...

BACKGROUND AND PURPOSE For CT scan planning, scan projection radiographs (SPR) are used. Tube tension and current for head SPR can be reduced to a minimum because of the small head diameter and because only high-contrast structures need to be visualized for planning. The goal of this study was to investigate SPR of the head in respect to effective doses, the influence of dose-reduction measures...

Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally...

Surface plasmon resonance (SPR) sensing is an optical technique that allows real time detection of small changes in the physical properties, in particular in the refractive index, of a dielectric medium near a metal film surface. One way to increase the SPR signal shift is then to incorporate a substance possessing a strong dispersive refractive index in the range of the plasmon resonance band....

INTRODUCTION Various optical measurement techniques have been developed for the characterization of surface states during electrochemical processes. Surface plasmon resonance (SPR) spectroscopy has been used in combination with electrochemistry to investigate the electronic structure of metal-electrolyte interfaces [1]. We reported the current efficiency of refractive index changes that occurre...

Sepiapterin reductase (SPR) is known as an essential enzyme for the biosynthesis of tetrahydrobiopterin. SPR belongs to the short-chain dehydrogenase/reductase (SDR) family and also reduces various exogenous carbonyl compounds including phenylpropanedione. We found in the present study that phenylpropanedione decreased the rate of proliferation of PC12 cells and that this rate was further dimin...

Fragment-based screening has recently evolved into a promising strategy in drug discovery, and a range of biophysical methods can be employed for fragment library screening. Relevant approaches, such as X-ray, NMR and tethering are briefly introduced focussing on their suitability for fragment-based drug discovery. In particular the application of surface plasmon resonance (SPR) techniques to t...

We anticipate that surface plasmon resonance (SPR) technology will remain the gold standard in direct biomolecular interaction sensing during the next decade. Although in the past only one company (Biacore AB) mainly dominated the market (B90%) of high-quality SPR systems including optics, liquid handling and sensor chips, new players and new trends can be identified. As highlighted in Chapter ...