Prostate-specific antigen (PSA) is a serine protease expressed at high levels in prostate epithelium, and elevated PSA in serum is a well-established marker of prostate cancer. Recently, the relative proportions of free PSA and PSA complexed to the serine protease inhibitor alpha 1-antichymotrypsin have become important variables in distinguishing between prostate cancer and benign prostatic hy...

BACKGROUND Few studies report estimates of cardiovascular disease (CVD) or major adverse cardiovascular events (MACE) in patients with psoriatic arthritis (PsA). OBJECTIVE To estimate rates of incident CVD and MACE in patients with PsA compared to patients without PsA. METHODS Using the Clinical Practice Research Datalink, we conducted 2 cohort studies of patients with PsA compared to patie...

PURPOSE Interestingly, prostate-specific antigen (PSA), which is used to monitor prostate disorders, has been suggested to be beneficial in estimating prognosis associated with coronary artery disease (CAD). The aim of the present study was to investigate the relationship of serum levels of PSA and free PSA (fPSA) with prognosis of acute coronary syndromes (ACS), extent of CAD and major adverse...

BACKGROUND In the AFFIRM trial, enzalutamide significantly increased overall survival (OS) for men with metastatic castration-resistant prostate cancer (mCRPC) after chemotherapy versus placebo and significantly decreased prostate-specific antigen (PSA) levels. The goal of this post hoc analysis was to associate levels of PSA decline from baseline after enzalutamide with clinical outcomes in th...

BACKGROUND The aim of our study was to identify the optimal predictor of prostate cancer among several prostate-specific antigen (PSA) derivatives in repeat prostate biopsy. METHODS We retrospectively assessed the repeat prostate biopsy specimens, obtained between 1999 and 2008, of 212 patients with a total PSA (tPSA) of 4-10 ng/ml and normal digital rectal examination. Using a receiver opera...

Bordetellosis, caused by Bordetella avium infection, is characterized by tracheal inflammation, epithelial cell degeneration, and tracheal distortion. The inflammation results from dermonecrotic toxins produced by B. avium. Inflammatory reactions are accompanied by generation of reactive oxygen metabolites (ROM) that kill cells. Antioxidant enzyme activity associated with either sodium selenite...

C-reactive protein (CRP) is an inflammatory protein released by the body in response to infection and injury. Elevation of this serum protein has been linked to increased risks of heart disease through inflammation that is believed to play a key role in the hardening of arteries resulting in a heart attack or stroke. Consequently, CRP could serve as a genetic marker for an eminent cardiac event...

Broiler starter diets from three commercial feed mills (same company, different locations) were fed to day-old Hubbard Hi-Y broiler chicks along with a Control diet manufactured at Ohio State University. The analyzed calcium levels were as follows: Source 1, .76% ; Source 2, .97% ; Source 3, .81 % ; Control, .98%. Each of the diets was fed to 5 replicate pens of broiler chicks in Petersime batt...

PURPOSE We evaluated predictors of prostate cancer-specific mortality (PCSM) after prostate-specific antigen (PSA) failure after radical prostatectomy (RP) or radiation therapy (RT). PATIENTS AND METHODS A total of 1,159 men with clinically localized prostate cancer treated with RP (n = 498) or RT (n = 661) developed PSA failure, and they formed the study cohort. Competing risk regression ana...

BACKGROUND The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with 18F-choline (CH) PET/CT after external beam radiation therapy (EBRT). METHODS In this retrospective study, data were collected from 54 patients with suspicion of PCa biochemical recurrence after EBRT (28 patients treated initially with EBRT and 26 as salvag...