BACKGROUND the T-786C polymorphism of the gene for endothelial nitric oxide synthase (eNOS) and superoxide anion production may reduce production and bioavailability of nitric oxide, affecting the degree of vasodilation. This effect can be reversed by exercise. OBJECTIVE to investigate the influence of aerobic training and T-786C polymorphism in the concentrations of nitric oxide metabolites ...

Reactive oxygen species (ROS) are an important endogenous source of DNA damage and oxidative stress in all cell types. Deficiency in tuberin resulted in increased oxidative DNA damage in renal cells. In this study, the role of tuberin in the regulating of ROS and NADPH oxidases was investigated. Formation of ROS and activity of NADPH oxidases were significantly higher in mouse embryonic fibrobl...

Glitazones have anti-inflammatory properties by interfering with the transcription of proinflammatory genes, such as cyclooxygenase (COX)-2, and with ROS production, which are increased in hypertension. This study analyzed whether pioglitazone modulates COX-2 expression in hypertension by interfering with ROS and endothelin (ET)-1. In vivo, pioglitazone (2.5 mg·kg(-1)·day(-1), 28 days) reduced ...

Oxidative stress (OS) is one of the factors that cause dementia conditions such as Alzheimer's disease and vascular dementia (VaD). In the pathogenesis of VaD, OS is associated with risk factors that include increased age, hypertension, and stroke. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a molecular source of reactive oxygen species (ROS). According to recent stu...

introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...

23 Anthropogenic emissions of nitrogen oxides (NOx ≡ NO + NO2) and carbon monoxide (CO) 24 affect particulate matter (PM) air quality on an intercontinental scale by changing background 25 concentrations of oxidants (OH, ozone, H2O2) and thus increasing the oxidation rate of sulfur 26 dioxide (SO2) to sulfate and NOx to nitrate. We conduct sensitivity simulations with the GEOS27 Chem chemical t...

By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). 8-bromo-cAMP stimulated NOx production and increased steady-state levels of iNOS mRNA in rat VSMC in ...

Pollutant emissions from combustion systems are a major area of concern with today’s energy needs. Numerical simulations have helped with the design of clean and efficient combustion strategies over the years. However, with the emergence of new fuels and combustion modes, it is necessary to improve the computational models. In this research, improved NOx and soot models are developed which uses...

The usage of lean-burn engines is a promising strategy for improving the fuel economy of vehicles and reducing the emission of greenhouse gas CO2. The most complex challenge for leanburn engines is the need to find a solution for the increased levels of NOx emissions. Lean NOx trap (LNT) or NOx storage-reduction (NSR) catalysts provide a very effective method for NOx removal in lean-burn gasoli...