Abscission is a developmental process that enables plants to shed unwanted organs. In Arabidopsis, the floral organ abscission is regulated by a signaling pathway consisting of the peptide ligand IDA, the receptor-like kinases (RLKs) HAE and HSL2, and a downstream MAP kinase (MAPK) cascade. However, little is known about the molecular link between ligand-receptor pairs and intracellular signali...

Inflammation can lead to malabsorption of important micronutrients such as iron. Malabsorption and nutritional deficiency can be caused by a variety of pathological and environmental factors causing a range of other symptoms commonly caused by both H. pylori infection and coeliac disease (CD). National guidelines suggest the routine taking of duodenal biopsies to exclude CD when investigating p...

Cristina Maria Areias, Benedita Sampaio-Maia, Hercilia Guimaraes, Paulo Melo, David Andrade I Odontopediatrics, Faculdade de Medicina Dentária da Universidade do Porto, Porto, PT. II Microbiology, Faculdade de Medicina Dentária da Universidade do Porto, Porto, PT. III Pediatrics, Faculdade de Medicina Universidade do Porto, Porto, PT. IV Dentistry, Faculdade de Medicina Dentária da Universidade...

Plants constantly renew during their life cycle and thus require to shed senescent and damaged organs. Floral abscission is controlled by the leucine-rich repeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA. It is unknown how expression of IDA in the abscission zone leads to HAESA activation. Here we show that IDA is sensed directly by the HAESA ectodomain. Crystal structures of H...

Background: Iron deficiency, is a common worldwide complication, especially in preschool children. Iron deficiency anemia (IDA) is associated with changes in the mental and motor development, defects of immune system, cardiovascular, diseases and disruption of lipid profile. In IDA, the occurrence of dyslipidemia is controversial. We aimed to investigate the association between IDA and serum li...

Iron deficiency anemia (IDA) is the most common cause of anemia in the United States, and it particularly affects women of child-bearing age and black, non-Hispanic race/ethnicity. During the surveillance period there were 10,157 incident ("new") cases of IDA among active component service members; the overall incidence rate was 7.1 per 10,000 person-years. The annual incidence rates increased...

OBJECTIVE To improve the quality of care provided to patients with iron deficiency anaemia (IDA). DESIGN Service development. SETTING District General Hospital. PATIENTS Adults with IDA. MAIN OUTCOME MEASURES Descriptive report of the practicalities and benefits of establishing an IDA clinic. CONCLUSIONS The IDA clinic is a novel service development which enhances the management of pa...

We have cloned and characterized the ida gene that is required for proliferation of imaginal disc cells during Drosophila development. IDA is homologous to APC5, a subunit of the anaphase-promoting complex (APC/cyclosome). ida mRNA is detected in most cell types throughout development, but it accumulates to its highest levels during early embryogenesis. A maternal component of IDA is required f...

OBJECTIVE To determine the impact of iron deficiency anemia (IDA) in pregnancy on young child development. METHODS A 2-year follow-up of 850 children born to women who participated in a double-blind cluster randomized controlled trial of prenatal micronutrient supplementation in western rural China. These women were randomly assigned to receive either daily folic acid, iron/folic acid (60 mg ...