The steroidal diamine irehdiamine A (IDA) is a potent inhibitor of bacteriophage growth and macromolecular synthesis in Escherichia coli. By using radioactive (42)K and (14)C-thiomethylgalactoside (TMG), rapid effects of IDA and related steroids, both on the influx of potassium and TMG via their respective transport systems and on the efflux (leakage) of radioactivity from the treated cells, ha...

Generation of induced dopaminergic (iDA) neurons may provide a significant step forward towards cell replacement therapy for Parkinson's disease (PD). To study and compare transcriptional programs of induced cells versus primary DA neurons is a preliminary step towards characterizing human iDA neurons. We have optimized a protocol to efficiently generate iDA neurons from human pluripotent stem ...

Uptake and efflux of two anthracyclines, idarubicin (IDA) and daunorubicin (DNR), was studied in childhood acute leukemia samples. A comparison of IDA and DNR transport phenomena in relation to drug cytotoxicity and expression of P-glycoprotein (PGP) was made. Intracellular content of IDA/DNR was determined by flow cytometry using the fluorescent properties of the drugs. In vitro drug cytotoxic...

The numbers of older people in the world have been growing rapidly. Anemia is the most common hematologic problem encountered in older adults. However, anemia should not be accepted as an inevitable consequence of aging. Anemia in the elderly signifi es an underlying disease. Iron Defi ciency Anemia (IDA) is being one of the most common causes of anemia in older people. IDA in the elderly is of...

BACKGROUND Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 hea...

Integrin αvβ3 is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides. In this study, the authors investigated the clinical efficacy and safety of a novel radiolabeled RGD peptide, 99mTc-IDA-D-[c(RGDfK)]2, for the imaging of integrin αvβ3 expression, as a measure of tumor angiogenesis in lung cancers and brain tumors. F...

There are both quantitative and methodological techniques that foster the development and maintenance of a cumulative knowledge base within the psychological sciences. Most noteworthy of these techniques is meta-analysis, which allows for the synthesis of summary statistics drawn from multiple studies when the original data are not available. However, when the original data can be obtained from...

Iron deûciency anemia (IDA) and beta-thalassemia trait (BTT) are the common causes of microcytic hypochromic anaemia. Several discrimination indices have been introduced to discriminate quickly these similar entities via parameters obtained from automated cell counter. The purpose of the study was to compare the value of two discrimination indices, red cell distribution width index (RDWI) and r...

Parallel disks can improve I/O performance in a manner analogous to the use of parallel processors to improve computation times. However, due to their data storage function, reliability issues become very important for these parallel disk systems. Currently proposed schemes use shadowing or parity to achieve reliability in parallel disks. In this paper we introduce the idea of using the Informa...

We present AIDA*, a generic adaptable scheme for highly parallel iterative-deepening search on large-scale asynchronous MIMD systems. AIDA* is based on a data partitioning scheme, where the di erent parts of the search space are processed asynchronously in parallel. Existing sequential solution algorithms can be linked to the AIDA* routines to build a fast, highly parallel search program. Takin...