1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]-piperazine (Lu AA21004) is a novel antidepressant that is currently in late-stage clinical development for major depressive disorder. In the present study, the metabolism of Lu AA21004 was investigated using human liver microsomes (HLM), human liver S9 fraction, and recombinant enzymes. Lu AA21004 was found in vitro to be oxidized to a 4-hydroxy-phenyl...

BACKGROUND Endothelin A (ETA) receptor antagonists have been shown to improve ventricular remodeling and survival in rats when started 10 days after infarction. Whether starting them earlier would have a more or less beneficial effect is uncertain. METHODS AND RESULTS Rats surviving an acute myocardial infarction (MI) for 24 hours (n=403) were assigned to saline or the ETA receptor antagonist...

Local hyperthermia and the hypoxic cytotoxin SR 4233 were administered to nude mice with 693 +/- 47 mm3 (mean +/- SE) s.c. HCT-8 human colonic adenocarcinoma xenografts in an attempt to enhance the antitumor effects of radioimmunotherapy. Biodistribution studies revealed preferential binding of NR-Lu-10, a murine monoclonal antibody, to the tumors compared with an isotype-matched control antibo...

AMA Lv L, Zhang M. Up-to-date literature review and issues of sedation during digestive endoscopy. Videosurgery Other Miniinvasive Techniques/Wideochirurgia i inne techniki małoinwazyjne. 2023. doi:10.5114/wiitm.2023.127854. APA Lv, L., & Zhang, (2023). https://doi.org/10.5114/wiitm.2023.127854 Chicago Lu-Lu, Meng-Meng Zhang. "Up-to-date endoscopy". Harvard MLA Lu-Lu et al. endoscopy." małoinwa...

The multifrontal LU method is implemented to solve drift-diffusion models with large sparse matrices arising in the simulation and optimization of semiconductor devices. The performance of this method is compared with the LU algorithm without multifrontal scheme on different computers in the case of a realistic double heterojunction transistor. Résumé On emploie un méthode LU multifrontale pour...

We surveyed areas of the state of Rondônia in western Amazon for phlebotomine, which are potential vectors of leishmaniasis. A total of 5,998 specimens were captured, resulting in the identification of 48 species within the Lutzomyia (99.98%) and Brumptomyia (0.02%) genera. The predominant species was Lutzomyia davisi, followed by Lutzomyia umbratilis, Lutzomyia llanosmartinsi, Lutzomyia c. car...

A male of a new species Micropygomyia (Micropygomyia) ancashensis sp. nov. and a female of the Lutzomyia (Helcocyrtomyia) chavinensis Pérez & Ogusuku, 1999 captured in the Antonio Raymondi province, department of Ancash, Peru are described and illustrated. The new species belongs to the cayennensis series, being closest to Mi. lewisi (Feliciangeli Ordoñez & Férnandez) though presenting highly s...

The natural fault-tolerant properties and regular structure of the Lee-Lu-Lee’s array multiplier over GF(2) fields make it very attractive for VLSI implementation. However, the Lee-Lu-Lee’s array multiplier is time-consuming while comparing with other existing array multipliers. Thus, we will present fast array multipliers with multiple speeds as comparing with the Lee-Lu-Lee’s array multiplier.