To maintain genomic integrity cells have to respond properly to a variety of exogenous and endogenous factors that produce genome injuries and interfere with DNA replication. DNA integrity checkpoints coordinate this response by slowing cell cycle progression to provide time for the cell to repair the damage, stabilizing replication forks and stimulating DNA repair to restore the original DNA s...

The use of sub-unit vaccines can solve some drawbacks associated with traditional attenuated or inactivated ones. However, in order to improve their immunogenicity, these vaccines needs to be associated to an appropriate adjuvant which, adequately selected, may also offer an alternative pathway for administration. The aim of this work was to evaluate the protection offered by the hot saline com...

To cope with ultraviolet C (UVC)-stalled replication forks and restart DNA synthesis, cells either undergo DNA translesion synthesis (TLS) by specialised DNA polymerases or tolerate the lesions using homologous recombination (HR)-based mechanisms. To gain insight into how cells manage UVC-induced stalled replication forks, we analysed the molecular crosstalk between the TLS DNA polymerases Polη...

Brucellosis is a zoonotic and economically significant animal disease worldwide. The most frequently used vaccine to avoid brucellosis in small ruminants the Rev1 conjunctival Brucella melitensis vaccine. aim of this study was investigate effects B.melitensis Revl on total protein, albumin, globulin levels, protein profiles oxidant/antioxidant status sheep. Ten sheep were as material for purpos...

seen in this study for verbs, in the processing of time and temporal structure [10]. While Shapiro et al. [3] are admirably restrained in their interpretations, they outline how their results suggest there is some relationship between grammatical class and semantic representations. This is a far from trivial issue: from a classic psycho-linguistic perspective, semantic and syntactic representat...

Abstract Brucellosis caused by Brucella abortus and melitensis is endemic in the Republic of Azerbaijan but a complex mix fiscal, political technical constraints has impeded regulatory authority decision making for adoption sustainable national control programme. This paper reports series epidemiologic studies disease animals humans which we conducted between 2009 2020. A preliminary study subs...