The effect of ergodisation (either by additional coils like in TEXTOR-DED or by intrinsic plasma effects like in W7-X) defines the need for transport models being able to describe this properly. A prerequisite for this is the concept of local magnetic coordinates allowing a correct discretization with minimized numerical errors [1]. For these coordinates the full respective metric tensor has to...

Wall conditioning in magnetic controlled fusion devices is a common tool to improve plasma performance and discharge reproducibility [1]. It will be relied upon in the next W7-X operation phases (OP1.2 in 2017-2018 and OP2 starting in 2020) to control the surface state of the plasmafacing components (PFC) with the eventual aim of providing access to continuous discharge operation [2]. The super...

The SAK cell line, derived from a spontaneous thymic lymphoma in an AKR mouse, is resistant to lysis by glucocorticoids in spite of the presence of functional glucocorticoid receptor. Receptor function was determined by hormone binding analyses, as well as characterization of hormonal effects on cell growth and on the accumulation of murine leukemia virus and metallothionein mRNAs. SAK cells we...

The N7 of purine nucleotides presents one of the most dominant metal ion binding sites in nucleic acids. However, the interactions between kinetically labile metal ions like Mg(2+) and these nitrogen atoms are inherently difficult to observe in large RNAs. Rather than using the insensitive direct (15)N detection, here we have used (2)J-[(1)H,(15)N]-HSQC (Heteronuclear Single Quantum Coherence) ...

The mechanisms of the action of bioactive compounds discovered via 'black box' assays using phenotypic indicators generally remain unknown, with the major challenges being the identification of target proteins. In this study, we aimed to develop an efficient methodology to unveil target proteins that are rarely characterised. Proof-of-concept experiments were performed using N-(6-aminohexyl)-5-...

First we will prove a small lemma. Lemma 1. Let P be a p-Sylow subgroup of G. Let N be a normal subgroup of G such that P ⊂ N . Then all p-Sylow subgroups are in N . Proof. Let P̃ be a p-Sylow subgroup that is not P . Then by the Sylow Theorems, we know that gPg−1 = P̃ for some g ∈ G. Since P ⊂ N , and N is normal, we know that gPg−1 ⊂ N and hence P̃ ⊂ N . Thus all p-Sylow subgroups are in N . Now...

Reciprocating probes are a classic and widespread tool for the investigation of edge Scrape-Off Layer magnetic fusion plasmas. In Wendelstein 7-X (W7-X) stellarator, Multi-Purpose Manipulator serves as multi-user platform probe measurements various kinds. This paper presents review on reciprocating operation during first phase W7-X with test divertor (2017-2018). It gives an overview diverse zo...

The major DNA adduct formed from the carcinogen ethylene dibromide (1,2-dibromoethane, EDB) is S-[2-(N7-guanyl)ethyl]glutathione, resulting from the reaction of guanyl residues with the half-mustard S-(2-bromoethyl)glutathione, which is generated by glutathione S-transferase-catalyzed conjugation of EDB with glutathione. The half-life of the alkylating species [putative S-(2-bromoethyl)glutathi...

Abstract In the previous divertor campaign, Wendelstein 7-X (W7-X) device injected 3.6 MW of neutral beam heating power allowing for achievement densities approaching 2 × 10 20 m −3 , and providing first initial assessment fast ion confinement in a drift optimized stellarator. The injection (NBI) system on W7-X is comprised two boxes with space four radio frequency sources each. reported this w...