نتایج جستجو برای: ایزوتوپهای 12 و 13 کربن
تعداد نتایج: 1518042 فیلتر نتایج به سال:
Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to initiate Bak homo-oligomerization. However, it is unclear how such tight binding can induce Bak homo-oligomerization. Here we report the ligand-induced Bak conformational changes observed in 3D models of Noxa·Bak and Bim·Bak refined by molecular dynamics simulations. In ...
In this paper, utilization of clustering algorithms for data fusion in decision level is proposed. The results of automatic isolated word recognition, which are derived from speech spectrograph and Linear Predictive Coding (LPC) analysis, are combined with each other by using fuzzy clustering algorithms, especially fuzzy k-means and fuzzy vector quantization. Experimental results show that the ...
Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains controversial. The indirect activation model suggests that they simply must neutralize all of the prosurvival Bcl-2 family members, whereas the direct activation model proposes that Bim and Bid must activate Bax and Bak directly. As numerous in vit...
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins. These interactions have been considered promiscuous, but our analysis of the affinity of eight BH3 peptides for five Bcl-2-like proteins has revealed that the interactions vary over 10,000-fold in affinity, and ...
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تا دهه اخیر بهینه سازی در فرآیندهای آهنگری بیشتر با مدل سازی فیزیکی و روش سعی و خطا در طراحی قالب همراه بود ولیکن امروزه همراه با رشد کامپیوتر و در نتیجه رشد روش اجزاء محدودد در شبیه سازی فرایندهای شکل دهی فلزات ، بهینه سازی در فرآیند آهنگری دچار تحول اساسی شده است . امروزه شبیه سازی عددی با المان محدود و اثبات تجربی آن یکی از قویترین ابزارهای موجود برای بهینه کردن فرآیند آهنگری است . از آنجائی...
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