BACKGROUND/AIMS Phagocytosis depends on the formation of engulfment pseudopodia surrounding the target. We tested in microglia, monocyte-derived cells in the brain, whether a swelling-activated Cl(-)-current (I(Cl,swell)), required for global cell volume (CV) regulation, also contributes to local expansion and retraction of engulfment pseudopodia. METHODS We used scanning electron microscopy ...

VISP MMK 2 SUMMARY The finite element (FE) method is a general method to model and simulate the physical behavior of bodies with arbitrary shape. There is a desire to create and use FE models early in the design process as well as to use the method detailing of complex artifacts. Modeling of the dynamic behavior of a multi-body system (MBS) is characterized by a composition of rigid bodies, int...

An immunohistochemical technique is described for the detection of Mallory bodies (MBs) in paraffin sections of liver tissue. This is based on proteolytic digestion of sections before exposure to an antiserum which recognises a unique antigenic determinant in MBs. With the use of this procedure it has been shown in alcoholic liver disease, primary biliary cirrhosis. Indian childhood cirrhosis, ...

Multibody system (MBS) computer codes currently being used are based on three-decade old technology that is failing to respond to new modeling challenges. Modern and complex ground vehicle models, for example, include significant details that cannot be captured using existing MBS software technology. This paper discusses a new Department of Defense (DoD) initiative focused on the development of...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are used to assess the role of prostaglandins in asthma but their effects on bronchoconstrictor challenges have been inconsistent. The effects of three nebulised nonsteroidal anti-inflammatory drugs on the airway response to inhaled sodium metabisulphite (MBS) and adenosine 5'-monophosphate (AMP) were compared in the same asthmatic subje...

Color is an inner, highly subjective experience only triggered by properties of light from the external world. Actual color perceptions are inextricably linked to (i) visual processing properties of observers that can vary greatly across individuals, and (ii) minor changes in viewing circumstances. Thus, it can be argued that color is not of this world, or, that color is not a veridical, or eve...

This work reports an amperometric biosensor for the determination of miRNA-21, a relevant oncogene. The methodology involves a competitive DNA-target miRNA hybridization assay performed on the surface of magnetic microbeads (MBs) and amperometric transduction at screen-printed carbon electrodes (SPCEs). The target miRNA competes with a synthetic fluorescein isothiocyanate (FITC)-modified miRNA ...

BACKGROUND The Medicare-rebated Health Assessment for Aboriginal and Torres Strait Islander People (Medicare Benefits Schedule [MBS] item number 715) has been progressively implemented across Australia since 1999. OBJECTIVE This paper explores some of the reasons why the uptake of Health Assessment for Aboriginal and Torres Strait Islander People remains low in some metropolitan general pract...