trichomoniasis is one of the most common urinary-genital tract disease. the causal agent of trichomoniasis is flagellate protozoan called trichomonas vaginalis. metronidazole and tinidazole are the drug of choice for treatment. carcinogenic and embryo-teratogenic effects of the mentioned drugs and resistance to metronidazole has been reported. according to cytotoxic effects of medicinal herbs i...

in the near future, design of a new generation of drugs targeting proteins will be required. considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. so far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. in these studies, use of spectroscopic method...

due to good biocompatibility, corrosion and mechanical properties, magnesium (mg) is considered promising degradable material for orthopedic applications. in this work, mg-mgznx (x= 1, 2, 3 and 4) nanocomposites scaffolds with different porosities were synthesized via powder metallurgy method. the microstructure, composition, in vitro corrosion and mechanical properties of porous magnesium-zinc...

background & aim: allium sativum commonly known as garlic is an herb used over years to prevent from various ailments such as cardiovascular diseases, cognitive disorders and also enhances the immune system. the aim of the present study is to study the in vitro antiarthritic and antihemolytic potential of garlic in aqueous and methanolic extracts. fourier transform infrared spectroscopy was per...

it has been investigated the in vitro antioxidant properties of ethanol extracts of the contained-allantoin plants in this study. contained-allantoined plant samples plantago lanceolata, plantago major, robinia pseudoacacia, platanus orientalis and aesculus hippocastanum were tested at different concentrations. the antioxidant activities of plant samples were analysed by 1,1- diphenyl-2-picrylh...

the aim of this study is to formulate a novel ophthalmic nanosuspension (ons), an alternative carrier system to traditional colloidal carriers for controlled release (cr) of acyclovir (acv). in the present study, ons is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

the present investigation was focused to formulate semi-solid capsules (sscs) of hydrophobic drug telmisartan (tlms) by encapsulating semi-solid matrix of its solid dispersion (sd) in hpmc capsules. the combinational approach was used to reduce the lag time in drug release and improvise its dissolution. sds of tlms was prepared using hot fusion method by varying the combinations of pluronic-f68...

background: the aim of this study was to assess effects of cysteamine as an anti-oxidant on rate of in vitro maturation of oocyte and determination of its effects on spindle size and shape. methods: pre-mature mice were primed with pregnant mare stimulating gonadotrophin (pmsg) and germinal vesicle (gv) stage oocytes were obtained 48 h after. the oocytes were cultured in tissue culture medium (...

background: leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. the present study was aimed to investigate antileishmanial effects of various extracts of berberis vulgaris also its active com-poenent, berberine against leishmania tropica and l. infantum species on in vitro ex-periments. methods : in this study in vitro antileishmanial activ...

background and objectives: current chemotherapies of cutaneous leihmaniasis have faced to some problems and limitations; development of new leishmanicidal drugs from different sources like herbal plants, are crucially important. the objective of the present study was evaluation of in vitro activity of alkanna frigida extracts in comparison with glucantime against leishmania major . materials an...