OBJECTIVES This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis. BACKGROUND Lp-PLA₂ has emerged as a potential therapeutic target in coronary heart disease. Data supporting Lp-PLA₂ are indirect and confounded by species differences; whether Lp-PLA₂ is causal in coronary heart disease remains in que...

Elevated levels of lipoprotein(a) (Lp(a)) have been identified as an independent risk factor for coronary heart disease. Plasma Lp(a) levels are reduced by monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). However, the mechanism of Lp(a) catabolism in vivo and the role of PCSK9 in this process are unknown. We report that Lp(a) internalization by hepatic HepG...

Let M be the Doob maximal operator on a filtered measure space and let v an Ap weight with 1<p<+∞. We try proving that ∥Mf∥Lp(v)≤p′[v]Ap1p−1∥f∥Lp(v), where 1/p+1/p′=1. Although we do not find approach which gives constant p′, obtain ∥Mf∥Lp(v)≤p1p−1p′[v]Ap1p−1∥f∥Lp(v), limp→+∞p1p−1=1.

For 0 < p < 1, Haberl and Ludwig defined the notions of symmetric and asymmetric Lp-intersection bodies. Recently, Wang and Li introduced the general Lp-intersection bodies. In this paper, we give the Lp-dual geominimal surface area forms for the extremum values and Brunn-Minkowski type inequality of general Lp-intersection bodies. Further, combining with the Lp-dual geominimal surface areas, w...

OBJECTIVES To investigate if serum Lp(a) lipoprotein (Lp(a)), a risk factor for atherosclerotic diseases, increases in patients with gout, who frequently also have atherosclerotic disease. METHODS Fasting blood samples were taken for measurement of Lp(a) and other variables in 175 male patients with primary gout. Serum concentrations of Lp(a) were measured by enzyme linked immunosorbent assay...

Although dendritic cells (DCs) located in the small intestinal lamina propria (LP-DCs) migrate to mesenteric lymph nodes (MLNs) constitutively, it is unclear which chemokines regulate their trafficking to MLNs. In this study we report that LP-DCs in unperturbed mice require CCR7 to migrate to MLNs. In vitro, LP-DCs expressing CCR7 migrated toward CCL21, although the LP-DCs appeared morphologica...

objective febrile convulsion is the most common benign convulsive disorder in children. meningitis is one of the most important causes of fever and convulsions, diagnosed by lumbar puncture (lp), a painful and invasive procedure much debated  regarding its necessity. this study evaluates the frequency of abnormal lp findings in a group of patients, to determine whether or not unnecessary lp can...

A classification of weakly compact multiplication operators on L(Lp), 1 < p < ∞, is given. This answers a question raised by Saksman and Tylli in 1992. The classification involves the concept of lp-strictly singular operators, and we also investigate the structure of general lp-strictly singular operators on Lp. The main result is that if an operator T on Lp, 1 < p < 2, is lp-strictly singular ...

EBNA-LP-associated proteins were identified by sequencing proteins that immunoprecipitated with Flag epitope-tagged EBNA-LP (FLP) from lymphoblasts in which FLP was stably expressed. The association of EBNA-LP with Hsp70 (72/73) was confirmed, and sequences of DNA-PK catalytic subunit (DNA-PKcs), HA95, Hsp27, prolyl 4-hydroxylase alpha-1 subunit, alpha-tubulin, and beta-tubulin were identified....