The Computed Tomography perfusion (CTp) is a promising tool in oncology to characterize tissue hemodynamics, but the difficulty achieve reproducible parameters several organs, with different methods, contributes hamper clinical translation of CTp. goal this study set up new approach aiming at achieving multicentre reproducibility blood flow (BF) values liver. 75 patients from two Centres (A and...

CTP has a growing role in evaluating stroke. It can be performed immediately following NCCT and has advantages of accessibility and speed. Differentiation of salvageable ischemic penumbra from unsalvageable core infarct may help identify patients most likely to benefit from thrombectomy or thrombolysis. Still, CTP interpretation can be complex. We review normal and ischemic perfusion patterns f...

We present a new approximation technique for quantum field theory. The standard one-loop result is used as a seed for a recursive formula that gives a sequence of improved Gaussian approximations for the generating functional. In a different setting, the basic idea of this recursive scheme is used in the second part of the paper to substantialy speed up the standard Monte Carlo algorithm. http:...

CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring CtpS polymerization and enzymatic activity, we show that polymerization inhibits activity, and CtpS's product, CTP, induces assembly. To understand h...

A new analog of EPO was designed by fusing one and two CTPs to the N-terminal and C-terminal ends of EPO (EPO-(CTP)(3)), respectively. This analog was expressed and secreted efficiently in CHO cells. The in vitro test shows that the activity of EPO-(CTP)(3) in TFI-1 cell proliferation assay is similar to that of EPO-WT and commercial rHEPO. However, in vivo studies indicated that treatment once...

PURPOSE The aim of this study was to compare diffusion-weighted magnetic resonance imaging (DWI) with computed tomography perfusion (CTP) for preoperative detection of metastases to lymph nodes (LNs) in head and neck squamous cell carcinoma (SCC). METHODS Between May 2010 and April 2012, 30 patients with head and neck SCC underwent preoperative DWI and CTP. Two radiologists measured apparent ...

Collaborative transportation planning (CTP) within a coalition of small and mid-sized freight carriers can be used as a powerful instrument to improve the operational efficiency of the coalition members. In such coalitions, transportation requests acquired from different freight carriers are exchanged among coalition members in order to reduce the total fulfillment costs. We consider the CTP fo...

In the structure of otolaryngological diseases, chronic tonsillopharyngitis (CTP) studied by us belongs to most common pathology in adult population (2.84-35%). The problem CTP treatment remains relevant, especially pregnant women, due diversity microflora and its influence on development outcome pregnancy. Based a comprehensive assessment results clinical, laboratory, immunological studies sta...

The heme-regulated eukaryotic initiation factor 2α (eIF2α) kinase, also known as inhibitor (HRI), detects misfolded proteins and induces cytoprotective response to stress, mainly caused by heme-shortage. nucleoside triphosphate ATP serves the main donor of phosphate for phosphorylation eIF2α HRI in human cells. However, other triphosphates (CTP, GTP, UTP) are present at relatively high concentr...

BACKGROUND AND PURPOSE In CT angiographic and perfusion imaging (CTA/CTP), rapid CT scanning is performed during the brief steady state administration of a contrast bolus, creating both vascular phase images of the major intracranial vessels and perfused blood volume-weighted parenchymal phase images of the entire brain. We assessed the added clinical value of the data provided by CTA/CTP over ...