Objective: Asafoetida (Ferula assa-foetida) is known as a valuable remedy for whooping cough, pneumonia, bronchitis in children and asthma treatment in folk medicine. In the present study the relaxant effects of the asafoetida on tracheal smooth muscle of guinea pigs and its probable mechanism(s) were examined. Materials and Methods: The relaxant effects of three cumulative concentrations of t...

Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarin have been previously tested for HSV treatment. Three sesquiterpene coumarins [badrakemin acetate (1), kellerin (2) and samarcandin diasteromer (3) ...

Based on the salp swarm algorithm (SSA), this paper proposes an efficient metaheuristic for solving global optimization problems and optimizing two commonly encountered geotechnical engineering structures: reinforced concrete cantilever retaining walls shallow spread foundations. Two new equations leader- followers-position-updating procedures were introduced in proposed adaptive (ASSA). This c...

Ferula turcica and latialata are two novel endemic species discovered in the Konya Kırşehir provinces of central Anatolian region Türkiye. These new described by morphological, ecological, carpological, phytochemical characteristics phylogenetic analysis. F. morphologically distinct from szowitsiana their habit, stalk terminal umbella, mericarp size, as well profile secondary metabolite markers...

Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identi...

Medical plants are adapted to different kinds of dormancy to survive in the worst situations. Regarding to ecological viewpoint, this kind of adaptation is very important in respect to restriction of genetic draft and decrease of genetic resource of medicinal plants. This leads to plant survival even after prolonged drought. Since some of them are endangered species and in the other hand increa...

Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarin have been previously tested for HSV treatment. Three sesquiterpene coumarins [badrakemin acetate (1), kellerin (2) and samarcandin diasteromer (3) ...

In this experiment, the chemical composition of the essential oils obtained from Ferula assa-foetida oleo-gum resin collected from two different sites of Yazd province (Tabas and Yazd) in the center of Iran, were identified. The gas chromatography mass-spectroscopy (GC/MS) data showed that the qualitative composition of the components appeare...