It has been widely postulated that the central mechanism of hepatic reperfusion injury involves the conversion, during ischemia, of the enzyme xanthine dehydrogenase (XDH) to its free radical-producing form, xanthine oxidase (XOD). However, this theory has been questioned because (a) XDH to XOD conversion in whole liver occurs very slowly; (b) the cellular distribution of XDH/XOD is unclear; an...

Retinoids influence growth and differentiation of keratinocytes (KCs) and are widely used for the management of skin diseases and for prevention of nonmelanoma skin cancer (NMSC) in predisposed patients. Here we investigated the effect of all-trans-retinoic acid (ATRA) on KC apoptosis. When KCs were cultured in confluent monolayers for several days, they acquired resistance against UVB-induced ...

The objective of this study was to compare the efficacy of two sources of omega 3 and 6, fish oil (FO) and linseed oil (LO), orally administered, alone or in combination, for treating experimentally induced keratoconjunctivitis sicca (KCS) in rabbits. Twenty-eight New Zealand rabbits were used in this study. Seven animals were allocated to the C group (negative control), and KCS was induced in ...

Hepatic ischemia/reperfusion (I/R) contributes to major complications in clinical practice affecting perioperative morbidity and mortality. Recent evidence suggests the key role of nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammaosme activation on the pathogenesis of I/R injury. Asiatic acid (AA) is a pentacyclic triterpene derivati...

Abstract Background Health utilities and health‐related quality of life (HRQoL) have not been adequately examined in patients with basal squamous cell carcinomas (or keratinocyte skin cancers KCs) repeatedly treated for multiple who require ongoing medical surveillance. Objectives Our aim was to assess whether health HRQoL an Australian population‐based sample recently KCs were poorer compared ...

Slac2-b, also known as exophilin-5, is a Rab27b effector protein with role in exosome transport and encoded by the EXPH5 gene. We previously described biallelic loss-of-function mutations an autosomal recessive form of epidermolysis bullosa simplex. However, how loss Slac2-b expression leads to skin fragility erosions unknown. In this study, we demonstrate that keratinocytes (KCs) isolat...

Prurigo nodularis (PN) is a chronic, inflammatory skin condition characterized by intensely pruritic, hyperkeratotic nodules that disproportionately affects Black patients. Little known about the interaction of innate immune cells with epithelial and stromal elements in PN. Thus, we utilize imaging mass cytometry (IMC) to examine cutaneous lymphocytic myeloid cell populations lesional PN skin, ...

BACKGROUND & AIMS While non-alcoholic steatohepatitis (NASH) is characterized by hepatic steatosis combined with inflammation, the mechanisms triggering hepatic inflammation are unknown. In Ldlr(-/-) mice, we have previously shown that lysosomal cholesterol accumulation in Kupffer cells (KCs) correlates with hepatic inflammation and cholesterol crystallization. Previously, cholesterol crystals ...

BACKGROUND Hepatocellular carcinoma (HCC) is associated with inflammation, and roughly 30 % of the global population shows serological evidence of current or past infection with hepatitis B or hepatitis C virus. Resident hepatic macrophages, known as Kupffer cells (KCs), are considered as the specific tumor-associated macrophages (TAMs) of HCC, and can produce various cytokines-most importantly...

Ships encounter different wave heights in real sea states. Various can lead to substantial changes the behaviour of a ship during manoeuvring, and hence ship's manoeuvrability waves should be accurately evaluated ensure navigational safety at sea. The aim this study is estimate height effects on manoeuvring benchmarking KRISO Container Ship (KCS) model by performing fully nonlinear unsteady RAN...