نتایج جستجو برای: آمیلوراید amiloride

تعداد نتایج: 2783  

Journal: :American journal of physiology. Renal physiology 2004
Lan Chen Catherine M Fuller Thomas R Kleyman Sadis Matalon

We studied the effects of two mutations of the extracellular loop of the alpha-subunit of the (ENaC) on amiloride-sensitive current in Xenopus laevis oocytes and the inhibition of this current by 3-morpholinosydnonimine (SIN-1). Injection of oocytes with wild-type (wt) alpha-,beta-,gamma-rENaC cRNA (8.3 ng/subunit) resulted 48-72 h later in inward Na(+) currents (-5.5 +/- 0.8 microA; means +/- ...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2006
Mona Lisa Chanda Jeffrey S Mogil

Amiloride is a nonspecific blocker of acid-sensing ion channels (ASICs) that have been recently implicated in the mediation of mechanical and chemical/inflammatory nociception. Preliminary data using a transgenic model are suggestive of sex differences in the role of ASICs. We report here that systemic administration of amiloride (10-70 mg/kg ip) produces a robust, dose-dependent blockade of la...

2009
Agnese Secondo Anna Pannaccione Pasquale Molinaro Paolo Ambrosino Pellegrino Lippiello Alba Esposito Maria Cantile Priti R. Khatri Daniela Melisi Gianfranco Di Renzo Lucio Annunziato

With the help of single-cell microflorimetry, Ca radiotracer fluxes, and patch-clamp in whole-cell configuration, we examined the effect of the amiloride derivative 3-amino-6-chloro-5[(4-chloro-benzyl)amino]-N-[[(2,4-dimethylbenzyl)amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) on the activity of the three isoforms of the Na /Ca exchanger (NCX) and on several other membrane currents including ...

Journal: :Antimicrobial agents and chemotherapy 1986
S Giunta L Galeazzi G Turchetti G Sampaoli G Groppa

Amiloride at millimolar concentrations caused marked changes in the growth-dependent intracellular balance of Na+ and K+ in Streptococcus faecalis. These results, whether specific to transport processes or resulting from indirect yet unknown mechanisms, constitute the first evidence of an effect of amiloride on bacterial electrolytes.

Journal: :The American journal of physiology 1998
Michael J Christ Lynn M Iwamoto Asoka de Silva Sarah L Lavallee Kenneth T Nakamura

Nebulized amiloride has been proposed as therapy in cystic fibrosis to block Na+ hyperabsorption in airway epithelium and prevent dehydration of secretions. Patients with cystic fibrosis often have reactive airways. Bovine and canine trachea relax to amiloride in vitro, suggesting another benefit as a bronchodilator, whereas guinea pig trachea, a useful model of human airways, does not. We hypo...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2002
Heimo Mairbäurl Katrin Mayer Kwang-Jin Kim Zea Borok Peter Bärtsch Edward D Crandall

Hypoxia has been reported to inhibit activity and expression of ion transporters of alveolar epithelial cells. This study extended those observations by investigating the mechanisms underlying inhibition of active Na transport across primary cultured adult rat alveolar epithelial cell monolayers grown on polycarbonate filters. Cell monolayers were exposed to normoxia and hypoxia (1.5% and 5% O(...

Journal: :BMC Endocrine Disorders 2005
Subhadra C Gunawardana W Steven Head David W Piston

BACKGROUND Amiloride derivatives, commonly used for their diuretic and antihypertensive properties, can also cause a sustained but reversible decrease of intracellular pH (pHi). Using dimethyl amiloride (DMA) on normal rodent pancreatic islets, we previously demonstrated the critical influence of islet pHi on insulin secretion. Nutrient-stimulated insulin secretion (NSIS) requires a specific pH...

Journal: :The American journal of physiology 1974
L C Stoner M B Burg J Orloff

STONER, L. C., M. B. BURG, AND J. ORLOFF. Ion transport in cortical collecting tubule; effect of amiloride. Am. J. Physiol. 227(2) : 453-459. 1974.-T b 1 u u es were dissected from rabbit kidneys and perfused in vitro. In cortical collecting tubules the transepithelial electrical potential difference (PD) was 35 mV (lumen negative). There was net active sodium reabsorption from the lumen and ne...

Journal: :The American journal of physiology 1988
R S Fisher J W Lockard

When toad urinary bladder or frog skin epithelia are treated with amiloride, short-circuit current (Isc), which represents the net active transepithelial Na+ transport rate from the apical to basolateral surface, decreases rapidly (2-5 s) to approximately 15-20% of control values and then slowly, over several minutes, continues falling toward zero. The contribution of this second phase of the d...

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