زمینه و هدف: مجموعة پروتئینی mTOR در پاسخ به تمرینات مقاومتی با رویکردی هیستولوژیکی افزایش هوازی سوخت‌وسازی کاهش می‌یابد. این تغییرات شرایط ابتلا دیابت نوع دو همراه ورزشی می‌تواند قابل بحث باشد. بدین‌منظور لحاظ کردن تمریناتی مانند تمرین تناوبی شدید دارا بودن ویژگی‌های بی‌هوازی از طرفی مداخلة تعامل احتمالی شاخص‌های گلایسمیک هیستوپاتولوژیکی قلب را تصویر بکشد. ازاین‌رو پژوهش حاضر برای تعیین تأثیر ...

هدف: هدف پژوهش حاضر بررسی ویژگی‌های روان سنجی مقیاس استرس آسیب‌زا کوید-19 بود که اثرات ویروس کرونا را بر جنبه‌های مختلف زندگی مردم ایران مورد قرار می‌دهد. روش:پژوهش توصیفی از نوع همبستگی بود. جامعۀ آماری شامل کلیۀ افرد بزرگسال شهر تهران در دامنۀ سنی 17 تا 72 سال 461 نفر طریق فراخوانی اینترنتی تحقیق شرکت کردند. برای تجزیه‌وتحلیل داده‌ها دو روی‌آورد کلاسیک و نظریۀ سؤال- پاسخ نرم­افزارهای Spss نسخ...

As explained beautifully in Warren Ewens’ chapter, mathematical models played a decisive role in reconciling Mendelian genetics with Darwin’s theory of evolution by natural selection. Out of this successful enterprise during the early 20th century, the field of population genetics emerged. Population genetics is concerned with the study of the genetic composition of populations. This compositio...

The purpose of this paper is to develop statistical tests of the neutral model of evolution against a class of alternative models with the common characteristic of having an excess of mutations that occurred a long time ago or a reduction of recent mutations compared to the neutral model. This class of population genetics models include models for structured populations, models with decreasing ...

In this paper, we use the multitype mean field voter model as a model of species interaction, to obtain results about species abundance. Briefly, we start with the complete graph on n vertices, Cn, with each site occupied by a particle. Particles are represented by a value in (0, 1), where distinct values represent different species. Particles then undergo mutation at rate α, and are relabelled...

The transmission/disequilibrium test (TDT) is widely used to detect the linkage disequilibrium between a candidate locus (a marker) and a disease locus. The TDT is a family-based design and has the advantage that it is a valid test when population stratification exists. The TDT requires the marker genotypes of affected individuals and their parents. For diseases with late age of onset, it is di...

Let (X n) be a residual allocation model with i.i.d. residual fractions U n. For a random variable W with values in 0; 1] independent of (X n) we deene another sequence (Y n) by setting Under minor regularity assumptions we show that (X n) and (Y n) have the same probability law if and only if this law is a GEM distribution. In this case, the distribution of W and the U n 's is beta (1;) for so...

In this report, we investigate the statistical power of several tests of selective neutrality based on patterns of genetic diversity within and between species. The goal is to compare tests based solely on population genetic data with tests using comparative data or a combination of comparative and population genetic data. We show that in the presence of repeated selective sweeps on relatively ...

Recurrence equations for the number of types and the frequency of each type in a random sample drawn from a finite population undergoing discrete, nonoverlapping generations and reproducing according to the Cannings exchangeable model are deduced under the assumption of a mutation scheme with infinitely many types. The case of overlapping generations in discrete time is also considered. The equ...

Many statistical tests have been developed for detecting positive selection. Most of these tests draw conclusions based on significant deviations from the patterns of polymorphism predicted by the neutral model. However, many non-equilibrium forces may cause similar deviations, and thus the tests usually have low statistical specificity to positive selection. The main challenge is hence to cons...