Hypoxia-ischemia (HI) is associated with premature birth, and injury during term birth. Many infants experiencing HI later show disruptions of language, with research suggesting that rapid auditory processing (RAP) deficits (i.e., impairment in the ability to discriminate rapidly changing acoustic signals), play a causal role in language problems. We recently bridged these lines of research by ...

BACKGROUND AND PURPOSE Perinatal hypoxia-ischemia (HI) produces acute and prolonged inflammation of the brain. Mast cells (MCs), numerous in the pia and CNS of neonatal rats, can initiate inflammation attributable to preformed mediators. MCs contribute to HI brain damage in the neonatal rat; MC stabilization protects through 48 hours of reperfusion. Here we hypothesize that HI induces early MC ...

Article history:Received 24 June 2008Revised 2 December 2008Accepted 3 December 2008Available online 24 December 2008Hypoxic–ischemic injury (HI) to the neonatal brain results in delayed neuronal death with accompanyinginflammation for days after the initial insult. The aim of this study was to depict delayed neuronal death afterHI using Manganese-enhanced MRI (MEMRI...

The hippocampus is injured in both hypoxia-ischemia (HI) and perinatal iron deficiency that are co-morbidities in infants of diabetic mothers and intrauterine growth restricted infants. We hypothesized that preexisting perinatal iron deficiency predisposes the hippocampus to greater injury when exposed to a relatively mild HI injury. Iron-sufficient and iron-deficient rats (hematocrit 40% lower...

We have previously shown that cycloheximide significantly inhibited apoptosis, and reduced ensuing cerebral infarction in a newborn rat model of cerebral hypoxiaischemia. This study was performed to determine the therapeutic window for cycloheximide therapy. Seven day-old newborn rat pups were subjected to 100 min of 8% oxygen following a unilateral carotid artery ligation, and cycloheximide wa...

Intense exercise stimulates the systemic release of a variety of factors that alter neutrophil surface receptor expression and functional activity. These alterations may influence resistance to infection after intense exercise. The aim of this study was to examine the influence of exercise intensity on neutrophil receptor expression, degranulation (measured by plasma and intracellular myelopero...

the aim of this work was to investigate the influence of interactions between modified starch (hi-cap 100) and the nonionic surfactant tween 80 on the properties of cardamom oil-in-water emulsion and its corresponding spray dried microcapsules. to this end the mean diameter and size distribution of droplets as well as their polydispersity index and also the viscosity and flow behavior of emulsi...

background and aims: influenza vaccination is one of the best way to prevent and control influenza worldwide. it is manufactured by who-licensed companies based on the who expertise committee annually. the aim of this study was partial quality control of the commercial human influenza vaccine 2008-9 and its matching with the circulating strains. materials and methods: the trivalent imported vac...

We present neutral hydrogen observations of 54 galaxies in the Pegasus cluster. The observations include single dish HI measurements, obtained with the Arecibo telescope for all 54 galaxies in the sample, as well as HI images, obtained with the VLA for 10 of these. The Arecibo profiles reveal an overall HI deficiency in the cluster, with ∼40% of the galaxies in the core of the cluster showing m...

The hemagglutination-inhibition (HI) test for antirhinovirus antibody was carried out on paired sera from volunteers inoculated with rhinovirus type 3 or type 4 (RV4). The HI test gave results which paralleled the neutralization test and was at least as sensitive as a microneutralization method for detection of serotype-specific antibody. Although high levels of HI antibody in the serum were as...