NF-κB transcription factors are the key regulators of innate and adaptive immune responses, inflammation, and cell survival [1]. Considerable evidences indicate that NF-κB plays important roles in carcinogenesis, cancer progression, metastasis and drug resistance, and therefore NF-κB has been regarded as one of the most important targets for cancer therapy [2]. However, the application of inhib...

Diffuse large B-cell lymphoma (DLBCL) comprises the largest group of non-Hodgkin lymphoma (NHL). DLBCL can be classified according to their cellular origin and patients with the activated B-cell (ABC) subtype have an inferior prognosis relative to those with the germinal center B-cell (GCB) subtype. Constitutive anti-apoptotic NF-κB signaling is a hallmark of ABC-DLBCL. NF-κB activation is caus...

Despite well-studied clinical manifestations, intracellular mechanisms of prolonged hyperthermic injury remain unclear, especially in skeletal muscle. Given muscle's large potential to impact systemic inflammation and metabolism, the response of muscle cells to heat-mediated injury warrants further investigation. We have previously reported increased activation of NF-κB signaling and increased ...

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, ...

BACKGROUND NF-κB activation, pathogen invasion, polymorphonuclear leukocytes (PMN) transmigration (PMNT) across the blood-brain barrier (BBB) are the pathogenic triad hallmark features of bacterial meningitis, but the mechanisms underlying these events remain largely unknown. Vimentin, which is a novel NF-κB regulator, is the primary receptor for the major Escherichia coli K1 virulence factor I...

Abstract Stimulation of the innate immune system is crucial in both effective vaccinations and immunotherapies. This often achieved through adjuvants, molecules that usually activate pattern recognition receptors (PRRs) stimulate two signaling pathways: nuclear factor kappa-light-chain-enhancer activated B-cells pathway (NF-κB) interferon regulatory factors (IRF). Here, we demonstrate ability t...

To assess possible effects of genkwanin (GKA) in septic lung injury and its related mechanisms. An animal model cecal ligation puncture (CLP)-induced acute was constructed. Histological analysis wet–dry (W/D) ratio the tissue were observed. The cell apoptosis this analyzed by caspase activity detection, protein levels B-cell lymphoma 2 (Bcl-2) Bcl-2-associated X (Bax), inflammation CLP model; a...

Introduction Stilbenoid compounds have been described to anti-inflammatory properties in animal models vivo , and shown inhibit Ca2+-influx through the transient receptor potential ankyrin 1 (TrpA1). Methods To study how stilbenoid affect inflammatory signaling we utilized fruit fly, Drosophila melanogaster as a model system. induce intestinal inflammation fed flies with irritant dextran sodium...

A study by Cheng et al. in this issue of Science Signaling highlights the distinct single-cell signaling characteristics conferred by pathways mediated by the adaptor proteins MyD88 and TRIF in the TLR4-dependent activation of the transcription factor nuclear factor κB (NF-κB).