Cell invasion through extracellular matrix (ECM) is a hallmark of the metastatic cascade. Cancer cells require adhesion to surrounding tissues for efficient migration to occur, which is mediated through the integrin family of receptors. Alterations in expression levels of β1 and β3 integrins have previously been reported in a number of human cancers. However, whether there are specific roles fo...

Hypertension, diabetes mellitus (especially type 2 diabetes mellitus), metabolic syndrome and obesity are rapidly growing public health problems. Sympathetic nerve activation is observed in obesity, hypertension and diabetes mellitus, which have strong genetic as well as environmental determinants. Reduced energy expenditure and resting metabolic rate are predictive of weight gain, and the symp...

Activation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) present potential new therapies for obesity and type 2 diabetes. Here, we examined the effects of β3-adrenergic stimulation on tissue-specific uptake and storage of free fatty acids (FFA) and its implications for whole body FFA metabolism in diet-induced obese rats using a multi-radiotracer technique. Male Wista...

BACKGROUND/AIMS Many candidate gene studies have revealed that polymorphisms of the 5'-flanking controlled SERT gene linked polymorphic region (5HTT-LPR) gene and G-protein β3 C825T gene might be associated with functional dyspepsia (FD) and irritable bowel syndrome (IBS). This study was performed to investigate polymorphisms of the 5HTT-LPR gene and G-protein β3 C825T gene in FD and IBS in Kor...

A collective Hamiltonian for the rotation–vibration motion of nuclei is considered, in which the axial quadrupole and octupole degrees of freedom are coupled through the centrifugal interaction. The potential of the system depends on the two deformation variables β2 and β3. The system is considered to oscillate between positive and negative β3-values, by rounding an infinite potential core in t...

This study was designed to investigate the biological effects of fish collagen peptide (FCP) on human osteoblasts. Human osteoblasts were treated with 0.1% FCP, which was the optimal concentration confirmed by the increase in alkaline phosphatase activity. After one, three, five and seven days of culture, the number of FCP-treated cells increased significantly compared with untreated cells. In ...

This work reports the synthesis of three multimeric RGD peptidomimetic-paclitaxel conjugates featuring a number of αV β3 integrin ligands ranging from 2 to 4. These constructs were assembled by conjugation of the integrin αV β3 ligand cyclo[DKP-RGD]-CH2 NH2 with paclitaxel via a 2'-carbamate with a self-immolative spacer, the lysosomally cleavable Val-Ala dipeptide linker, a multimeric scaffold...

Bu çalışmada İzmir Orman Bölge Müdürlüğü (OBM) sınırları içinde kullanılmak üzere, varlığı ve ekonomik değeri ile önemli bir orman ağacı türü olan fıstıkçamı (Pinus pinea L.)’nın tek çift girişli dikili kabuklu gövde hacim tabloları düzenlenmiştir. amaçla, OBM genelinde 275 adet örnek ağaçta ölçü yapılarak gerekli veri elde edilmiştir. Ağaçların 44’ü kontrol, 231’i model geliştirme grubu olarak...

Cartilage is an avascular, alymphatic, and aneurysmal structure, so it difficult to heal properly if injury occurs. Using Chondrogenic Adipose Mesenchymal Stem Cell (AdMSC) secretome as adjuvant one of the therapeutic options overcome problem cartilage. Storage distribution problems must be solved we use this method. This study aims characterize Freeze-dried chondrogenic AdMSC secretome. Secret...