BACKGROUND β-blockers prevent cardiac arrhythmias in patients with chronic heart failure and reduced left ventricular ejection fraction, including ventricular tachycardia/ventricular fibrillation (VT/VF). We hypothesized that prevention of ventricular arrhythmias by the β-blocker/sympatholytic agent bucindolol is influenced by genetic variation in adrenergic receptors. METHODS AND RESULTS Fro...

BACKGROUND AND PURPOSE The histamine H₄ receptor, originally thought to signal merely through Gαi proteins, has recently been shown to also recruit and signal via β-arrestin2. Following the discovery that the reference antagonist indolecarboxamide JNJ 7777120 appears to be a partial agonist in β-arrestin2 recruitment, we have identified additional biased hH₄R ligands that preferentially couple ...

G-protein-coupled receptors (GPCRs) are known to activate both G protein- and β-arrestin-dependent signalling cascades. The initiation of mitogen-activated protein kinase (MAPK) pathways is a key downstream event in the control of cellular functions including proliferation, differentiation, migration and apoptosis. Both G proteins and β-arrestins have been reported to mediate context-specific a...

Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but the cellular target that mediates its profibrotic actions has not been clearly identified. While in vitro data suggest that TGF-β-induced matrix production is mediated by renal fibroblasts, the role of these cells in TGF-β-dependent tubulointerstitial fibrosis following renal injury is not well defined...

Silibinin is a natural flavonoid with anti-diabetic activity. Glucagon-like peptide−1 (GLP−1), an intestinal hormone mainly secreted from L cells, which regulates insulin production and sensitivity, appears to be potential therapeutic strategy for T2DM. The current study aims determine the protective effect of silibinin against palmitic acid (PA)-induced damage in GLUTag cells. results revealed...

Abstract Background β-blockers are one of the four recommended disease-modifying classes drugs for treatment heart failure with reduced ejection fraction (HFrEF). Although their efficacy and prognostic role is unquestionable in general population HFrEF patients, differences effect relation to sex have not been yet investigated detail. The present study analyzed a large, real-world, Italian pati...

Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to investigate the combination therapeutic effect of these cells with insulin and metformin on neuropeptide Y, melanoco...

Some short-chain fatty acids with a pungent or unpleasant odor are important components of human body odor. These malodors severely threaten health. The antagonists would help to improve perception by affecting the interaction between odors and their receptors. However, traditional detection analysis methods, such as MOS, electrochemical, conductive polymer gas sensors, chromatography-mass spec...

Abstract CD8 +T cells are critical components of the immune reaction against viral infections and cancer have potential to eliminate infected or malignant cells. However, when antigen persists, enter an exhausted state. Chronic disease can lead increased systemic noradrenaline (NA) levels, but it is currently still unclear how NA impacts differentiation function We here set out characterize eff...

ABSTRACT Hypertension causes significant mortality and morbidity around the world. The β-adrenergic blockers are one of most commonly prescribed hypertension medications. Several with different pharmacological qualities have been developed, which may be grouped into three generations based on differences in properties. In this narrative review, we addressed evidence-based literature about role ...