Bibenzyl natural products, such as the amorfrutins, contain a heavily substituted aromatic core and display diverse range of biological activities (anti-tumor, anti-diabetic, antimicrobial, antibiotic). In this study, we report unified syntheses amorfrutin A to D either through total or formal synthesis by employing dual biomimetic strategy polyketide aromatization followed remote terpene funct...

in this research, (carboxy-3-oxopropylamino)-3-propylsilylcellulose (copapsc) as an organocatalyst, has been synthesized by grafting of succinic anhydride on the nh2-modified cellulose (cellulose functionalized with 3- aminopropyltriethoxysilane). the –co2h group-functionalized cellulose (copapsc) is used as a catalyst for the synthesis of coumarin derivatives from the reaction of phenolic subs...

The title compound, C(15)H(19)NO(5), is bent with a dihedral angle of 61.8 (2)° between the mean planes of the benzene ring and a group encompassing the ester functionality (O=C-O-C). The dihedral angle of 0.8 (2)° between the mean planes of the nitro group and the benzene ring indicates near coplanarity. In the crystal, each mol-ecule is linked to four adjacent mol-ecules by weak C-H⋯O hydroge...

The combination of gold(I) and enzyme catalysis has provided access to a series nor(pseudo)ephedrine derivatives in regio- stereoselective manner. approach involves developing IPrAuNTf2-catalyzed hydration 1-phenylprop-2-yn-1-yl acetate or N-(1-phenylprop-2-yn-1-yl)acetamide, followed by (dynamic) asymmetric biotransamination bioreduction the corresponding keto ester amide intermediates. Enzyme...

The protonation constants of alanine and alanine methyl ester were determined in different aqueous solutions of 1,4-dioxane containing (0-50% v/v), using a potentiometric method at 25o C and constant ionic strength 0.1 mol.L-1 (NaCl). The protonation constants were analyzed in terms of Kamlet, Abboud and Taft (KAT) parameters. The results show that the effect of β is higher in comparison with t...