Domperidone Maleate (DOM), an antiemetic drug, has been used in treatment of adults and children. It has low aqueous solubility and hence low bioavailability. In present study, an attempt has been made to enhance the solubility of DOM by inclusion complexation with Hydroxypropyl-βCyclodextrin (HP-β-CD) using kneading technique and formulation of fast disintegrating tablets by using Sodium Starc...

Zein nanofibers containing cyclodextrins (zein/CD) were produced via electrospinning. Three types of CDs (α-CD, β-CD and γ-CD) having 10%, 25% and 50% (w/w) were individually incorporated into zein nanofibers. SEM imaging elucidated that the morphologies of the electrospun zein/CD nanofibers depended on the CD type and weight percentage. The incorporation of CDs in zein improved the electrospin...

A mesoporous silica nanoparticle (MSN) based fluorescent sensor for dopamine was constructed with probes inside particle pores and β-cyclodextrin (β-CD) molecules on the particle surface as the selective barricade. The synergistic action of both the hydrophilic rim and hydrophobic cavity of β-CD ensures that the sensor can distinguish dopamine from other biological competitors.

This paper reports a stimuli-responsive designer supramolecular polymer gel in dimethylsulphoxide (DMSO)/water (1:2) based on dipeptide amphiphile and β-cyclodextrin (β-CD) The contains caproic acid at the N terminus methyl ester C terminus. From X-ray single crystal diffraction, adopts kink-like conformation. self-assembled to form parallel sheet-like structure stabilized by multiple intermole...

A 2,2-diphenyl-1-picrylhydrazyl radical (DPPH˙) was successfully solubilised in water by β-cyclodextrin (β-CD). DPPH˙/β-CD thus obtained was demonstrated to be a powerful tool to evaluate the antioxidative activity of water-soluble antioxidants, such as ascorbate and Trolox, in aqueous buffer solutions.

The aim of the present study was encapsulation cedar (Juniperus phoenicea) essential oil (CEO) Greek origin in β-cyclodextrin (β-CD) through formation inclusion complexes (ICs) using co-precipitation method with different β-CD-to-CEO weight ratios (90:10, 85:15, 80:20, 70:30 (w/w)). CEO β-CD host–guest interactions confirmed by Nuclear Magnetic Resonance (NMR) spectroscopy, FT-IR Differential S...

Density functional theory (DFT) calculations based on the BLYP-D4 and PBEh-3c composite methods were performed for investigating encapsulation mode of pentachlorophenol (PCP) inside cavity β-cyclodextrin (β-CD). Different quantum chemical parameters such as HOMO, LUMO, HOMO–LUMO gap calculated. Complexation energies computed at molecular level to provide insight into inclusion PCP β-CD cavity. ...

Platonia insignis Mart, Clusiaceae, known as bacuri, is a species native to Brazil that, in studies with extract of the seed its fruit, showed antioxidant activity against free radicals. Products such properties may be great importance treatment peptic ulcers since this pathology associated inflammatory process caused by action Cyclodextrins are molecules capable forming inclusion complexes oth...

This study aims to prove the complexation of cefpodoxime proxetil (CP) by hydroxypropyl-βcyclodextrin (HP-βCD) in the presence of sodium carboxymethyl cellulose (Na CMC), and investigates the permeability of CP in the complexes. The CP–HP-β-CD complex was prepared by kneading method and was characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR) and D...

The β-cyclodextrins (β-CD) as supramolecular have extremely attractive pharmaceutical applications. This study focused on the effects of macrocyclic systems complexation stability, antioxidant activities, and bioavailability optimized synthesis coumarin incorporating hydrazone moiety. Optimal (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)ethylidene)benzohydrazide (7-diEAHC) was performed by...