OBJECTIVE Impaired microcirculation is one of the most important factors in delayed wound healing. The aim of the study was to investigate the influence of chemical and surgical interruption of sympathetic nerve fibers and α- and β-receptors blockers on muscular microcirculation. METHODS The experiment was performed on a standardized cremaster muscle model of male Wistar rats (n=51). Microcir...

BACKGROUND AND AIMS Resistant hypertension is defined as failure to achieve blood pressure lower than 140/90 mmHg when using three antihypertensive agents or controlled blood pressure with four or more drugs. We aimed at assessing the prevalence of resistant hypertension and to describe a type 2 diabetes population with resistant hypertension. METHODS The retrospective observational study inc...

Aim . To assess the healthcare system costs for management of patients with heart failure (HF) based on a retrospective analysis primary medical documentation. Material and methods We performed outpatient records 1000 patients, followed up 1 year by general practitioner or cardiologist in ambulatory clinic 7 Russian regions. The study included men women over 18 years age an established class II...

BACKGROUND Preoperative β-blockade has been posited to result in better outcomes for vascular surgery patients by attenuating acute hemodynamic changes associated with stress. However, the incremental effectiveness, if any, of β-blocker usage in blunting heart rate responsiveness for vascular surgery patients who avoid general anesthesia remains unknown. METHODS We reviewed an existing databa...

The classifi cation of αand β-adrenoceptors by Ahlquist and colleagues in 1948 provided the foundation for the development of drugs that could modulate the sympathetic nervous system (SNS) [1]. The fi rst β-blocker, pronethalol, developed by Sir James Black, was limited clinically due to safety concerns. However, the subsequent development of its successor, propranolol, earned Black the Nobel P...

BACKGROUND The objective of this study is to examine practice-level variation in rates of guideline-recommended treatment for outpatients with heart failure and reduced ejection fraction, and to examine the association between treatment variation and practice site, independent of patient factors. METHODS AND RESULTS Cardiology practices participating in the National Cardiovascular Disease Reg...