The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival. In addition, ß-catenin is localized at the cell membrane and may influence the function of channels. The present study explored the possibility that ß-catenin participates in the regulation of the HERG K(+) channel. To this end, HERG ...

Previous studies of the relationship between the endogenous opioid system and alcohol consumption have reported contradictory results. To shed light on this connection, we compared plasma concentrations of beta-endorphin, adrenocorticotropic hormone, and cortisol in 70 alcoholic persons after different periods of abstinence and a group of 80 control subjects. Plasma beta-endorphin was decreased...

It has been demonstrated that analgesia induced by physiological stress (1. 6) and electro-acupuncture (8) may be mediated through an endogenous opioid mechanism. It is also known that acute stressful stimuli cause a concomitant release of ,8-endorphin and adrenocorticotropin (ACTH) from the pituitary gland (4). Both these are peptides derived from a common precursor molecule (7) and the releas...

BACKGROUND Few studies have systematically investigated insomnia in adults with epilepsy. METHODS We performed a prospective cross-sectional investigation of the prevalence, severity, and comorbidities of insomnia in 90 adults with epilepsy using a battery of self-reported instruments and polysomnography. We quantified insomnia severity using the Insomnia Severity Index (ISI). RESULTS Fifty...

The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in h...

The reporter gene for ß-galactosidase is frequently used to determine the efficiency of gene transfer in arteries. However, blood is often present in arterial explants and may compromise the results by the presence of hemoglobin. The light absorption of hemoglobin is similar to the absorption of several colorimetric products of the commonly used ß-galactosidase substrates, including onitropheny...

Bu çalışmanın amacı, Spor Bilimleri Fakültesinde (SBF) öğrenim gören öğrencilerin, öğrenme stili tercihleri ve öz kontrollü durumlarının akademik başarılarına etkisini araştırmaktır. Nicel araştırma yöntemlerinden, ilişkisel tarama modelinin kullanıldığı araştırmanın çalışma grubunu, SBF’de 2021-2022 yılda gören, kolay örnekleme yöntemi ile seçilen 348 gönüllü öğrenci oluşturmuştur. Çalışmada v...

Background: Magnetic resonance imaging (MRI) is becoming increasingly important in axial spondyloarthritis (SpA) due to its unique role early diagnosis, classification, and monitoring of disease (1, 2). It the only assessment tool that has been validated with histological inflammatory cellularity tissue biopsy sacroiliac (SI) joint (3). However, many MRI lesions are not exclusive SpA may occur ...

Understanding the antibiotic susceptibility of Salmonella enterica is important both from a clinical treatment and a public health perspective. The emergence of extended spectrum ß-lactamases (ESßLs) and AmpC ß-lactamases in S. enterica is important, as this will limit treatment options and could provide a strain with a significant selective advantage. The aim of the study was to screen isolate...

Behavioral synchrony has been linked to endorphin activity (Cohen et al., 2010; Sullivan and Rickers, 2013; Sullivan et al., 2014; Tarr et al., 2015, 2016; Weinstein et al., 2016). This has been called the synchrony effect. Synchrony has two dominant phases of movement; in-phase and anti-phase. The majority of research investigating synchrony's effect on endorphin activity has focused on in-pha...