The structures of diphenyl [3-methyl-1-(3-phenylthioureido)butyl]phosphonate and diphenyl [2-methyl-1-(3-phenylthioureido)butyl]phosphonate, both C(24)H(27)N(2)O(3)PS, are reported. In both compounds, the thiourea moiety adopts a syn-syn conformation (i.e. the S-C-N-C torsion angles are synperiplanar), which enables N-H...O hydrogen bonds to be formed between centrosymmetrically related molecul...

Although natural products have been a particularly rich source of human medicines, activity-based screening results in a very high rate of rediscovery of known molecules. Based on the large number of natural product biosynthetic genes in microbial genomes, many have proposed "genome mining" as an alternative approach for discovery efforts; however, this idea has yet to be performed experimental...

The importance of phosphorus can be highlighted not only through its biological significance, but also in its many varied industrial, medicinal, and synthetic applications. Phosphonate moieties in particular have broad applications including their use as reagents in the Horner-Wadsworth-Emmons olefination reaction, a widely used synthetic strategy. As an alternative to the often harsh condition...

The title compound, [Zr(CH(3))(C(15)H(39)N(4)Si(3))], is a unique example of a triamido-amine-supported zirconium-methyl complex that crystallized as a monomer with trigonal-bipyramidal geometry at zirconium, featuring a Zr-C bond of 2.2963 (16) Å.

A general, atom-economical method for the synthesis of phosphaalkenes is reported via the net coupling of primary alkyl or aryl phosphines with aryl or alkyl isocyanides at zirconium. The phosphorus-containing ligand can be liberated as the phosphaformamide from zirconium by reaction with an organic electrophile.

A 16-year-old woman with congenitally missing permanent mandibular second premolars and central incisors presented for treatment. The prosthodontic treatment consisted of placing 2 internal tri-lobed narrow platform implants in the mandibular second premolar spaces, along with zirconium abutments and all-ceramic crowns. A 4-unit zirconium fixed partial denture was fabricated to restore the miss...

Divalent metal complexes of macrocyclic ligand 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic acid)) (1,8-H4te2p, H4L) were investigated in solution and in the solid state. The majority of transition-metal ions form thermodynamically very stable complexes as a consequence of high affinity for the nitrogen atoms of the ring. On the other hand, complexes with Mn2+, Pb2+ and alkaline e...

Using N-(phosphonomethyl) iminodiacetic acid (H4PMIDA), as a complexing agent, two new complexes, (NH4)La(PMIDA)(H2O)•H2O, 1 and (NH4)Yb(PMIDA), 2 have been synthesized hydrothermally. In both compounds, the metal ions are trapped by a three five-membered chelate rings by the chelating PMIDA anions giving a tricapped trigonal prismatic LaO8N and monocapped trigonal prismatic YbO6N geometries fo...

It was shown in the preceding paper that incubation of the rabbit polymorphonuclearleukocyteswith phosphonate esters leads to an irreversible inhibition of the ability of the leukocyte to respond to the chemotactic factor. This "cell-dependent inhibition" was attributed to the inactivation by the phosphonates of an esterase existing in or on the leukocyte in an already activated state. As shown...

The exchange of the monocarboxylate ligand of the zirconium methacrylate oxocluster Zr(6)O(4)(OH)(4)(OMc)(12) (OMc = CH(2)=CH(CH(3))COO) with dicarboxylic acids (trans,trans muconic acid and terephthalic acid) leads to porous zirconium dicarboxylates exhibiting the UiO-66 architecture; the mild reaction conditions allow the control of their particle size.