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Ajaxon, I. 2017. Can Bone Void Fillers Carry Load? Behaviour of Calcium Phosphate Cements Under Different Loading Scenarios. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1492. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9865-8. Calcium phosphate cements (CPCs) are used as bone void fillers and as complements to hardware ...

Depending upon local conditions, brushite (CaHPO4 x 2 H2O) cements may be largely resorbed or (following hydrolysis to hydroxyapatite) remain stable in vivo. To determine which factors influence cement resorption, previous studies have investigated the solution-driven degradation of brushite cements in vitro in the absence of any cells. However, the mechanism of cell-mediated biodegradation of ...

The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the harde...

Hidroxyapatyte is a natural mineral found in teeth and bones. It is commonly used as a filler to regenerate bone or as a coating to promote bone growth. The application of calcium phosphate cements, which can form hydoxyapatite, in the treatment of bone defects, begun more than two decades ago and many formulations have been developed so far. The ideal bone replacing cement should be osteocondu...

Calcium phosphate cements (CPCs) are widely used in bone repair. Currently there are two main types of CPCs, brushite and apatite. The aim of this project was to evaluate the mechanical properties of particularly promising experimental brushite and apatite formulations in comparison to commercially available brushite- and apatite-based cements (chronOS(™) Inject and Norian(®) SRS(®), respective...

In the present study, series of Zn incorporated calcium sulfate bone cements, with different amounts of doped Zn(0, 0.74, 1.97, 3.05, 4.21 wt %) were prepared by mixing a calcium sulfate hemihydrate powder and solutions of zinc sulfate, and the effect of zinc-doping on some physical, physico-chemical, and biological properties of the cements were investigated. Pure calcium sulfate cement was al...

The surface-modified zinc phosphate (Zn3(PO4)2) nanocrystals were synthesized by a facile and efficient one-step ultrasonic-template-microwave (UTM) assisted route. The crystal structure, optical properties and morphologies of zinc phosphate nanocrystals were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy and transmission electron microscope. And...

epoxy powder coatings containing zinc aluminum phosphate (zap) and zinc phosphate (zp), which are the 2nd and 1st generation of phosphate-based pigments respectively, were applied to the surface of mild steel sheets. the anticorrosive performances of the coated samples were studied using electrochemical impedance spectroscopy (eis). cathodic disbonding resistance and the adhesion performance of...

Neutrophils release free zinc to eliminate the phagocytosed bacterial pathogen Streptococcus pyogenes (Group A Streptococcus; GAS). In this study, we investigated the mechanisms underpinning zinc toxicity towards this human pathogen, responsible for diseases ranging from pharyngitis and impetigo, to severe invasive infections. Using the globally-disseminated M1T1 GAS strain, we demonstrate that...