background:childhood zinc deficiency is a common problem in many developing countries where people rely mainly on plant based diets with low zinc contents. zinc supplementation is one of strategies to combat zinc deficiency and its consequences in children. the aim of this community trial was to examine the effect of zinc supplementation on the linear growth of children 6-24 months of age and t...

Zinc is ubiquitous in all living cells. Structural and catalytic properties of cellular enzymes are zinc dependent. Zinc deficiency leads to a variety of pathological abnormalities with immune impairment. It is an established fact that nutritional status contributes to overall immune response of individuals. Outcome of zinc deficiency on immune system is so drastic that it is difficult to conce...

The influence of zinc deficiency on the modulation of the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase (ERK1/2), p38, and c-Jun N-terminal kinase (JNK) was studied. Using human IMR-32 cells as a model of neuronal cells, the role of oxidants on MAPKs and activator protein-1 (AP-1) activation in zinc deficiency was investigated, characterizing the participation ...

Hepatic zinc deficiency has been well documented in alcoholic patients, but the mechanisms by which zinc deficiency mediates cell death have not been well defined. The objectives of this study were to determine whether alcohol perturbs subcellular zinc homeostasis and how organelle zinc depletion may link with cell death pathways. Wistar rats were pair-fed with the Lieber-DeCarli control or eth...

Zinc deficiency results in reduced testicular angiotensin-converting enzyme (ACE) activity and reduced amounts of ACE protein in the testes of young rats. In the present study, we examined the effect of zinc deficiency on the relative abundance of testicular ACE mRNA and its relationship to ACE activity over time. Forty-five male rats at 7 wk of age were placed on one of three feeding regimens:...

Abnormal taste acuity and zinc depletion have been reported with endstage renal disease. In order to determine when altered taste and zinc deficiency begin in the course of chronic progressive renal disease and to assess the various indices of zinc depletion, 14 pediatric patients were studied who were in various degrees of renal failure. They were not yet on dialysis or in need of transplantat...

There is concern regarding the absorption of zinc, both from dietary intake and nutritional supplements, because of zinc’s essential role in human nutrition and metabolism, and because of evidence that some population groups have a marginal to deficient intake of zinc. While oral zinc supplementation is efficacious in most zinc deficiency conditions, not all zinc preparations have equal bioavai...

BACKGROUND Zinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed. METHODS/PRINCIPAL FINDINGS Conditional knockout of the intestinal zinc transporter Zip4 (Slc39a4) in mice creates a model of the lethal human genetic dise...

Zinc is essential in the metabolic activities body including protein, DNA and RNA synthesis. It plays a role neurogenesis, maturation, migration of neurons synapse formation. high hippocampal which involved learning memory. Deficiency zinc during pregnancy has been related to many congenital abnormalities foetal nervous system. Furthermore insufficient levels children associated with lowered ab...